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Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36 alpha signaling pathway

文献类型：期刊论文

作者Qi, Qing1; Li, Qian1,2; Zhu, Hongwen1; Lu, Huimin1,3; Yang, Xiaoqian1; Wu, Yanwei1; Feng, Chunlan1; Fan, Chen1; Li, Heng1,3; Wu, Bing1,3
刊名PHARMACOLOGICAL RESEARCH
出版日期2021-07-01
卷号169页码:11
ISSN号1043-6618
关键词Triptolide LLDT-8 Psoriasis IL-36 alpha IL-36 alpha pathway Inflammation
DOI10.1016/j.phrs.2021.105678
通讯作者Zhou, Hu(zhouhu@simm.ac.cn) ; Zuo, Jianping(jpzuo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要Triptolide has shown a good immunosuppressive effect on autoimmune diseases. However, the toxicity limited its widely clinical practice. In this study, we investigated the effects and underlying mechanisms of (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, on a murine psoriasis-like dermatitis model and related cell lines. Here, we showed that LLDT-8 significantly attenuated symptoms of psoriasis-like dermatitis induced by imiquimod (IMQ, a TLR7 agonist) by reducing the psoriasis area and severity index (PASI) score and inflammatory parameters. The action of LLDT-8 was involved in down-regulated interleukin (IL)-36 alpha expression and blocked IL-36 alpha pathway by LC-MS-based label-free quantitative (LFQ) proteomic approach and further experiments. Meanwhile, we observed that LLDT-8 significantly inhibited the expression of IL-36 alpha in R837-treated bone marrow-derived dendritic cells (BMDCs). In conclusion, LLDT-8 notably alleviated IMQ-induced psoriasis-like skin inflammation via suppressing the IL-36 alpha signaling pathway, suggesting LLDT-8 might be a potential drug for the treatment of psoriasis.
WOS关键词SKIN INFLAMMATION ; (5R)-5-HYDROXYTRIPTOLIDE LLDT-8 ; EXPRESSION ; IL-36 ; IMMUNOSUPPRESSANT ; INHIBITION ; RECEPTORS ; PROTEINS ; LIGANDS ; DISEASE
资助项目National Natural Science Foundation of China[82003762]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号WOS:000663005100055
源URL[http://119.78.100.183/handle/2S10ELR8/296844]  
专题中国科学院上海药物研究所
通讯作者Zhou, Hu; Zuo, Jianping; Tang, Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Shanghai Univ, Sch Life Sci, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Qing,Li, Qian,Zhu, Hongwen,et al. Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36 alpha signaling pathway[J]. PHARMACOLOGICAL RESEARCH,2021,169:11.
APA Qi, Qing.,Li, Qian.,Zhu, Hongwen.,Lu, Huimin.,Yang, Xiaoqian.,...&Tang, Wei.(2021).Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36 alpha signaling pathway.PHARMACOLOGICAL RESEARCH,169,11.
MLA Qi, Qing,et al."Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36 alpha signaling pathway".PHARMACOLOGICAL RESEARCH 169(2021):11.

入库方式： OAI收割

来源：上海药物研究所

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