Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature
文献类型：期刊论文
| 作者 | Sui, Jian1,2,3; Tang, Chunping1,2 ; Ke, Chang-Qiang1,2; Ye, Yang1,2,3,4
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 152页码:7 |
| 关键词 | Bletilla striata Phenanthrene bibenzyl atropisomer LC-CD Bletistriatins A-D Bi(9 10-dihydro)phenanthrene |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2021.104919 |
| 通讯作者 | Ye, Yang(yye@simm.ac.cn) |
| 英文摘要 | Four pairs of undescribed racemic bi(9,10-dihydro) phenanthrene and phenanthrene/bibenzyl atropisomers, bletistriatins A-D (1 & ndash;4), along with 22 known compounds were isolated from the rhizomes of Bletilla striata. These dimeric derivatives were constructed through direct C & ndash;C connection or an oxygen bridge. The structures of new compounds were fully established by extensive analysis of MS, and 1D and 2D NMR spectroscopic data. Owing to sterically hindered rotation around the biaryl axis, these dimeric 9,10-dihydrophenanthrene derivatives can exist as a pair of enantiomers, but were isolated as racemates. Their racemates were separated to yield enantiomerically pure compounds by HPLC on an optically active stationary phase, and were stereochemically characterized on-line by circular dichroism (CD) spectroscopy (LC-CD coupling). Some isolates were evaluated for cytotoxicity against human cancer cell lines HL-60 and A549. Compounds 13, 17, and 20 showed cytotoxicity against HL-60 and A-549 cell lines with IC50 values ranging from 2.56 to 8.67 mu M. |
| WOS关键词 | CHEMICAL-CONSTITUENTS ; PHENANTHRENES ; BIPHENANTHRENES ; TUBERS ; PLANT |
| 资助项目 | National Natural Science Foundation of China[21920102003] ; Science and Technology Commission of Shanghai Municipality[20430780300] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000663829000010 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296858]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sui, Jian,Tang, Chunping,Ke, Chang-Qiang,et al. Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature[J]. FITOTERAPIA,2021,152:7. |
| APA | Sui, Jian,Tang, Chunping,Ke, Chang-Qiang,&Ye, Yang.(2021).Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature.FITOTERAPIA,152,7. |
| MLA | Sui, Jian,et al."Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature".FITOTERAPIA 152(2021):7. |
入库方式： OAI收割
来源：上海药物研究所
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