Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
文献类型：期刊论文
| 作者 | Khosroshahi, Siamak Farajzadeh2; Yin, Xianzhen1; Donat, Cornelius K.3,5; McGarry, Aisling3; Lopez, Maria Yanez3; Baxan, Nicoleta4; Sharp, David J.3; Sastre, Magdalena3; Ghajari, Mazdak2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2021-06-21 |
| 卷号 | 11期号:1页码:12 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-021-92371-0 |
| 通讯作者 | Khosroshahi, Siamak Farajzadeh(s.f.khosroshahi@imperial.ac.uk) |
| 英文摘要 | Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood-brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial stresses depending on their alignment with the principal direction of stress in parenchyma, with a better alignment leading to larger stresses in vessels. We also found a strong correlation between axial stress in vessels and the shearing component of the stress wave in parenchyma. Our multiscale computational approach explains the unrecognised role of the vascular anatomy and shear stresses in producing distinct distribution of large forces in vasculature. This new understanding can contribute to improving TBI diagnosis and prevention. |
| WOS关键词 | TRAUMATIC BRAIN-INJURY ; HEAD-INJURY ; BARRIER ; IMPACT ; DISRUPTION ; INFLAMMATION ; DEFORMATION ; NEUROTRAUMA ; CORTEX ; DAMAGE |
| 资助项目 | Wellcome Trust[212430/Z/18/Z] ; Wellcome Trust Networks of Excellence ; Royal British Legion Centre for Blast Injury Studies, Imperial College London |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000667261900015 |
| 出版者 | NATURE RESEARCH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296871]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Khosroshahi, Siamak Farajzadeh |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Imperial Coll London, Dyson Sch Design Engn, London, England 3.Imperial Coll London, Dept Brain Sci, London, England 4.Imperial Coll London, Biol Imaging Ctr, London, England 5.Imperial Coll London, Ctr Blast Injury Studies, London, England |
| 推荐引用方式 GB/T 7714 | Khosroshahi, Siamak Farajzadeh,Yin, Xianzhen,Donat, Cornelius K.,et al. Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses[J]. SCIENTIFIC REPORTS,2021,11(1):12. |
| APA | Khosroshahi, Siamak Farajzadeh.,Yin, Xianzhen.,Donat, Cornelius K..,McGarry, Aisling.,Lopez, Maria Yanez.,...&Ghajari, Mazdak.(2021).Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.SCIENTIFIC REPORTS,11(1),12. |
| MLA | Khosroshahi, Siamak Farajzadeh,et al."Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses".SCIENTIFIC REPORTS 11.1(2021):12. |
入库方式： OAI收割
来源：上海药物研究所
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