Neolinulicin A and B from Inula japonica and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Wu, Rui-fang2,3; Zhou, Bing-duo1; Wang, Wen-qiong2; Chen, Tong2; Xu, Ting-ting1; Zhu, Sheng-liang1; Xuan, Li-jiang2,3
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 152页码:6 |
| 关键词 | Inula japonica Sesquiterpenes Anti-inflammation |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2021.104905 |
| 通讯作者 | Xuan, Li-jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | A phytochemical study performed on Inula japonica led to isolation of a new 1,10-seco-sesquiterpene dimer Neolinulicin A (1) and 1,10-seco-sesquiterpene Neolinulicin B (2), together with nine known sesquiterpenes (3-11). Among them, Neolinulicin A (1), which has a new carbon skeleton, was a Diels-Alder [4 + 2] adduct of two sesquiterpene moieties. Their structures were established by extensive spectroscopic analysis. All of the isolated compounds showed inhibition of NO production in RAW 264.7 macrophages. The findings might supply information for the future design of anti-inflammatory agents from I. japonica. |
| WOS关键词 | SESQUITERPENES ; CONSTITUENTS ; DIMERS ; FLOWER ; NO |
| 资助项目 | Drug Innovation Major Project of China[2018ZX09735001-002-005] ; National Natural Science Foundation of China[81773863] ; Science and Technology Commission of Shanghai Municipality[18401932600] ; Youth Innovation Promotion Association[2019284] ; National Science and Technology Major Project[2019ZX09201004003-041] ; National Science and Technology Major Project[2019ZX09201004-003-042] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000670372000003 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296877]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Li-jiang |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Dept Gastroenterol, Yueyang Hosp Integrated Tradit Chinese & Western, 110 Ganhe Rd, Shanghai 200437, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Rui-fang,Zhou, Bing-duo,Wang, Wen-qiong,et al. Neolinulicin A and B from Inula japonica and their anti-inflammatory activities[J]. FITOTERAPIA,2021,152:6. |
| APA | Wu, Rui-fang.,Zhou, Bing-duo.,Wang, Wen-qiong.,Chen, Tong.,Xu, Ting-ting.,...&Xuan, Li-jiang.(2021).Neolinulicin A and B from Inula japonica and their anti-inflammatory activities.FITOTERAPIA,152,6. |
| MLA | Wu, Rui-fang,et al."Neolinulicin A and B from Inula japonica and their anti-inflammatory activities".FITOTERAPIA 152(2021):6. |
入库方式： OAI收割
来源：上海药物研究所
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