Honokiol: A naturally occurring lignan with pleiotropic bioactivities
文献类型：期刊论文
| 作者 | Chen Cheng1; Zhang Qing-Wen1; Ye Yang2 ; Lin Li-Gen1
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 19期号:7页码:481-490 |
| ISSN号 | 2095-6975 |
| 关键词 | Honokiol Natural sources Ethnopharmacological uses Physicochemical properties Bioactivities Clinical trials |
| DOI | 10.1016/S1875-5364(21)60047-X |
| 通讯作者 | Lin Li-Gen(ligenl@um.edu.mo) |
| 英文摘要 | Honokiol is the dominant biphenolic compound isolated from the Magnolia tree, and has long been considered as the active constituent of the traditional Chinese herb, 'Houpo', which is widely used to treat symptoms due to 'stagnation of qi'. Pharma-cological studies have shown that honokiol possesses a wide range of bioactivities without obvious toxicity. Honokiol protects the liver, kidneys, nervous system, and cardiovascular system through reducing oxidative stress and relieving inflammation. Moreover, honokiol shows anti-diabetic property through enhancing insulin sensitivity, and anti-obese property through promoting browning of adipocytes. In vivo and in vitro studies indicated that honokiol functions as an anti-cancer agent through multiple mechanisms: inhibiting angiogenesis, promoting cell apoptosis, and regulating cell cycle. A variety of therapeutic effects of honokiol may be associated with its physiochemical properties, which make honokiol readily cross the blood brain barrier and the blood-cerebrospinal fluid barrier, with high bioavailability. In the future, more clinical researches on honokiol are needed to fully authenticate its therapeutic values. |
| WOS关键词 | ANTIDEPRESSANT-LIKE SYNERGISM ; INDUCED CELLULAR-RESPONSES ; ACTIVATED PROTEIN-KINASE ; ALCOHOLIC FATTY LIVER ; KAPPA-B ACTIVATION ; MAGNOLIA-OFFICINALIS ; IN-VITRO ; INSULIN-RESISTANCE ; SIGNALING PATHWAY ; OXIDATIVE STRESS |
| 资助项目 | National Natural Science Foundation of China[81872754] ; Science and Technology Development Fund, Macau SAR[FDCT 0031/2019/A1] ; University of Macau[MYRG2017-00109-ICMS] ; University of Macau[MYRG2018-00037-ICMS] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| WOS记录号 | WOS:000671867000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296920]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lin Li-Gen |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen Cheng,Zhang Qing-Wen,Ye Yang,et al. Honokiol: A naturally occurring lignan with pleiotropic bioactivities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2021,19(7):481-490. |
| APA | Chen Cheng,Zhang Qing-Wen,Ye Yang,&Lin Li-Gen.(2021).Honokiol: A naturally occurring lignan with pleiotropic bioactivities.CHINESE JOURNAL OF NATURAL MEDICINES,19(7),481-490. |
| MLA | Chen Cheng,et al."Honokiol: A naturally occurring lignan with pleiotropic bioactivities".CHINESE JOURNAL OF NATURAL MEDICINES 19.7(2021):481-490. |
入库方式： OAI收割
来源：上海药物研究所
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