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Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment

文献类型：期刊论文

作者Xie, Qin1,5; Ding, Jian1,2,3; Chen, Yi1,4
刊名ACTA PHARMACEUTICA SINICA B
出版日期2021-06-01
卷号11期号:6页码:1365-1378
关键词CD8(+) T lymphocyte Stromal cell Tumor microenvironment Immunosuppression Immunotherapy Antitumor
ISSN号2211-3835
DOI10.1016/j.apsb.2021.03.027
通讯作者Ding, Jian(jding@simm.ac.cn) ; Chen, Yi(ychen@simm.ac.cn)
英文摘要CD8(+) T lymphocytes are pivotal cells in the host response to antitumor immunity. Tumor-driven microenvironments provide the conditions necessary for regulating infiltrating CD8(+) T cells in favor of tumor survival, including weakening CD8(+) T cell activation, driving tumor cells to impair immune attack, and recruiting other cells to reprogram the immune milieu. Also in tumor microenvironment, stromal cells exert immunosuppressive skills to avoid CD8(+) T cell cytotoxicity. In this review, we explore the universal function and fate decision of infiltrated CD8(+) T cells and highlight their antitumor response within various stromal architectures in the process of confronting neoantigen-specific tumor cells. Thus, this review provides a foundation for the development of antitumor therapy based on CD8(+) T lymphocyte manipulation. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
WOS关键词CANCER-ASSOCIATED FIBROBLASTS ; INHIBITORY RECEPTORS ; IMMUNE ESCAPE ; B7 FAMILY ; TGF-BETA ; ABERRANT EXPRESSION ; PD-1 EXPRESSION ; LUNG-CANCER ; CTLA-4 ; ACTIVATION
资助项目Strategic Priority Research Program of the Chinese Academy of Science[XDA12020101] ; National Natural Science Foundation of China[81773763]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000664915700003
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/296937]  
专题新药研究国家重点实验室
通讯作者Ding, Jian; Chen, Yi
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Shanghai HaiHe Pharmaceut Co Ltd, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310012, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Qin,Ding, Jian,Chen, Yi. Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment[J]. ACTA PHARMACEUTICA SINICA B,2021,11(6):1365-1378.
APA Xie, Qin,Ding, Jian,&Chen, Yi.(2021).Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment.ACTA PHARMACEUTICA SINICA B,11(6),1365-1378.
MLA Xie, Qin,et al."Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment".ACTA PHARMACEUTICA SINICA B 11.6(2021):1365-1378.

入库方式： OAI收割

来源：上海药物研究所

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