Small-molecule fluorescence-based probes for interrogating major organ diseases
文献类型：期刊论文
| 作者 | Han, Hai-Hao1,2; Tian, He, Jr.1,2; Zang, Yi3 ; Sedgwick, Adam C.4; Li, Jia3; Sessler, Jonathan L.4; He, Xiao-Peng1,2; James, Tony D.5,6
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| 刊名 | CHEMICAL SOCIETY REVIEWS
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| 出版日期 | 2021-07-07 |
| 页码 | 39 |
| ISSN号 | 0306-0012 |
| DOI | 10.1039/d0cs01183e |
| 通讯作者 | Li, Jia(jli@simm.ac.cn) ; Sessler, Jonathan L.(sessler@cm.utexas.edu) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; James, Tony D.(t.d.james@bath.ac.uk) |
| 英文摘要 | Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases. |
| WOS关键词 | HYPOCHLOROUS ACID ; MONOAMINE-OXIDASE ; HYDROGEN-PEROXIDE ; AMYLOID PLAQUES ; MICE ; MODELS ; VISUALIZATION ; FLUCTUATION ; HEALTH ; BRAINS |
| 资助项目 | National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; China Postdoctoral Science Foundation[2020M681196] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] ; Robert A. Welch Foundation[F-0018] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000670372900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296967]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jia; Sessler, Jonathan L.; He, Xiao-Peng; James, Tony D. |
| 作者单位 | 1.East China Univ Sci & Technol, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 4.Univ Texas Austin, Dept Chem, 105 E 24th St,A5300, Austin, TX 78712 USA 5.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 6.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Hai-Hao,Tian, He, Jr.,Zang, Yi,et al. Small-molecule fluorescence-based probes for interrogating major organ diseases[J]. CHEMICAL SOCIETY REVIEWS,2021:39. |
| APA | Han, Hai-Hao.,Tian, He, Jr..,Zang, Yi.,Sedgwick, Adam C..,Li, Jia.,...&James, Tony D..(2021).Small-molecule fluorescence-based probes for interrogating major organ diseases.CHEMICAL SOCIETY REVIEWS,39. |
| MLA | Han, Hai-Hao,et al."Small-molecule fluorescence-based probes for interrogating major organ diseases".CHEMICAL SOCIETY REVIEWS (2021):39. |
入库方式： OAI收割
来源：上海药物研究所
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