Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents
文献类型：期刊论文
| 作者 | Zhang, Cong1,2; Li, Heng3; Liu, Jin1; Liu, Moting3; Zhang, Hao1; Chen, Kai-Xian1,4 ; Guo, Yue-Wei1,4; Tang, Wei3; Li, Xu-Wen1,4
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2021-06-01 |
| 卷号 | 111页码:8 |
| ISSN号 | 0045-2068 |
| 关键词 | Marine natural product Cembranoid Anti-inflammation molecular docking structuremodification Structure Activity Relationship |
| DOI | 10.1016/j.bioorg.2021.104887 |
| 通讯作者 | Tang, Wei(tangwei@simn.ac.cn) ; Li, Xu-Wen(xwli@simn.ac.cn) |
| 英文摘要 | Eleven novel cembranoid derivatives were designed, synthesized, and evaluated for their inflammation related activities on the basis of our isolated and previously reported anti-inflammatory marine cembranoids. In bioassay, compound 11 displayed the most promising inhibitory effects with IC50 value of 1.1 mu M for the TNF-alpha inhibitory activity. The further mechanism study of 11 on the inflammatory signaling transduction of RAW264.7 cells was also performed. This research may give an insight for the discovery of marine cembranoid derived antiinflammatory drug leads. |
| WOS关键词 | DITERPENOIDS ; INHIBITORS ; ALPHA |
| 资助项目 | National Natural Science Foundation of China (NSFC)[82022069] ; National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[42076099] ; Shanghai RisingStar Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ06] ; Science & Technology Commission of Shanghai Municipality, China[18431907100] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000656967400010 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297001]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tang, Wei; Li, Xu-Wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Irumunophammcol, Shanghai 201203, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Cong,Li, Heng,Liu, Jin,et al. Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents[J]. BIOORGANIC CHEMISTRY,2021,111:8. |
| APA | Zhang, Cong.,Li, Heng.,Liu, Jin.,Liu, Moting.,Zhang, Hao.,...&Li, Xu-Wen.(2021).Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents.BIOORGANIC CHEMISTRY,111,8. |
| MLA | Zhang, Cong,et al."Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents".BIOORGANIC CHEMISTRY 111(2021):8. |
入库方式： OAI收割
来源：上海药物研究所
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