Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
文献类型：期刊论文
| 作者 | Wang, Yaya1; Cao, Qiao1,2; Cao, Qin1,3; Gan, Jianhua4; Sun, Ning5; Yang, Cai-Guang1,3,6 ; Bae, Taeok7; Wu, Min8; Lan, Lefu1,3,6,9
|
| 刊名 | SCIENCE BULLETIN
 |
| 出版日期 | 2021-06-15 |
| 卷号 | 66期号:11页码:1101-1118 |
| 关键词 | Pseudomonas aeruginosa Histamine Metabolism Host-microbe interaction Virulence |
| ISSN号 | 2095-9273 |
| DOI | 10.1016/j.scib.2021.01.002 |
| 通讯作者 | Lan, Lefu(llan@simm.ac.cn) |
| 英文摘要 | During infections, bacteria stimulate host cells to produce and release histamine, which is a key mediator of vital cellular processes in animals. However, the mechanisms underlying the bacterial cell & rsquo;s ability to sense and respond to histamine are poorly understood. Herein, we show that HinK, a LysR-type transcriptional regulator, is required to evoke responses to histamine in Pseudomonas aeruginosa, an important human pathogen. HinK directly binds to and activates the promoter of genes involved in histamine uptake and metabolism, iron acquisition, and Pseudomonas quinolone signal (PQS) biosynthesis. The transcriptional regulatory activity of HinK is induced when histamine is present, and it occurs when HinK binds with imidazole-4-acetic acid (ImAA), a histamine metabolite whose production in P. aeruginosa depends on the HinK-activated histamine uptake and utilization operon hinDAC-pa0222. Importantly, the inactivation of HinK inhibits diverse pathogenic phenotypes of P. aeruginosa. These results suggest that histamine acts as an interkingdom signal and provide insights into the mechanism used by pathogenic bacteria to exploit host regulatory signals to promote virulence. (c) 2021 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
| WOS关键词 | TRANSCRIPTIONAL REGULATOR ; GENE-EXPRESSION ; BIOGENIC-AMINES ; MAST-CELLS ; HOST ; BACTERIA ; INFECTION ; FAMILY ; COMMUNICATION ; INDUCTION |
| 资助项目 | Ministry of Science and Technology (MOST) of China[2016YFA0501503] ; Ministry of Science and Technology (MOST) of China[2019ZX09721001004003] ; National Natural Science Foundation of China[31670136] ; National Natural Science Foundation of China[31870127] ; National Natural Science Foundation of China[81861138047] ; Science and Technology Commission of Shanghai Municipality[19JC1416400] ; State Key Laboratory of Drug Research[SIMM2003ZZ03] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000656697400010 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297010]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lan, Lefu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Northwest Univ, Coll Life Sci, Xian 710069, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai 201438, Peoples R China 5.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chem Biol & Drug Discovery, Hong Kong 999077, Peoples R China 6.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 7.Indiana Univ Sch Med Northwest, Dept Microbiol & Immunol, Gary, IN 46408 USA 8.Univ North Dakota, Dept Biomed Sci, Grand Forks, ND 58203 USA 9.Shanghai Inst Food & Drug Control, NMPA Key Lab Testing Technol Pharmaceut Microbiol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yaya,Cao, Qiao,Cao, Qin,et al. Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa[J]. SCIENCE BULLETIN,2021,66(11):1101-1118. |
| APA | Wang, Yaya.,Cao, Qiao.,Cao, Qin.,Gan, Jianhua.,Sun, Ning.,...&Lan, Lefu.(2021).Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa.SCIENCE BULLETIN,66(11),1101-1118. |
| MLA | Wang, Yaya,et al."Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa".SCIENCE BULLETIN 66.11(2021):1101-1118. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。