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Copper-mediated ortho C-H primary amination of anilines

文献类型：期刊论文

作者Cheng, Tai-Jin1,2; Wang, Xing1,2; Xu, Hui1; Dai, Hui-Xiong1,2
刊名TETRAHEDRON LETTERS
出版日期2021-06-08
卷号73页码:5
关键词Copper catalyst C-H activation Primary amination Late-stage diversification
ISSN号0040-4039
DOI10.1016/j.tetlet.2021.153099
通讯作者Xu, Hui(xuhui2018@simm.ac.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要We report herein a copper-mediated ortho C-H primary amination of anilines by using cheap and commercially available benzophenone imine as the amination reagent. The protocol show good functional group tolerance and heterocyclic compatibility. Late-stage diversification of drugs demonstrate the synthetic utility of this protocol. (C) 2021 Elsevier Ltd. All rights reserved.
WOS关键词CATALYZED SYNTHESIS ; ARENES ; BONDS ; AMIDE ; (HETERO)ARENES ; ALKYNYLATION ; AMMONIA ; AMINES
资助项目Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[21772211] ; National Natural Science Foundation of China[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000656983400008
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/297013]  
专题中国科学院上海药物研究所
通讯作者Xu, Hui; Dai, Hui-Xiong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Tai-Jin,Wang, Xing,Xu, Hui,et al. Copper-mediated ortho C-H primary amination of anilines[J]. TETRAHEDRON LETTERS,2021,73:5.
APA Cheng, Tai-Jin,Wang, Xing,Xu, Hui,&Dai, Hui-Xiong.(2021).Copper-mediated ortho C-H primary amination of anilines.TETRAHEDRON LETTERS,73,5.
MLA Cheng, Tai-Jin,et al."Copper-mediated ortho C-H primary amination of anilines".TETRAHEDRON LETTERS 73(2021):5.

入库方式： OAI收割

来源：上海药物研究所

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