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Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis

文献类型：期刊论文

作者Xiang, Caigui1,2; Liu, Moting1,2; Lu, Qiukai1,2; Fan, Chen1; Lu, Huimin1,2; Feng, Chunlan1; Yang, Xiaoqian1; Li, Heng1; Tang, Wei1,2
刊名CELLULAR IMMUNOLOGY
出版日期2021-07-01
卷号365页码:10
ISSN号0008-8749
关键词Ulcerative colitis Caffeic acid Toll-like receptors Macrophages
DOI10.1016/j.cellimm.2021.104364
通讯作者Li, Heng(liheng@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要Ulcerative colitis (UC) represents a relapsing and inflammatory bowel disease which is commonly linked with the communications between dysfunction of epithelium and mucosal immune responses. Though caffeic acid (CA) has numerous pharmacological capacities, whether CA demonstrates immunoregulation on the mucosal immune responses remains ill-defined. Herein, the present research demonstrated that CA could dramatically attenuate the mucosal inflammation, as evidenced by improving the disease severity, serum biochemical indexes, mucosal ulcerations, loss of epithelium and crypts, and secretion of inflammatory cytokines in the colonic homogenates and explants culture. Consistently, CA could interfere with the infiltration and function of mononuclear macrophages in the mucosa, MLNs, and spleens of UC. Furthermore, CA exerted direct suppressive effects on the activation of BMDMs upon the exposure of TLRs agonists in vitro. Taken together, CA could attenuate DSSinduced murine UC through interfering with the activation of macrophages, which might provide an alternative therapeutic option for UC.
WOS关键词NF-KAPPA-B ; PHENETHYL ESTER ; IN-VIVO ; APOPTOSIS ; DISEASE ; BARRIER ; CELLS ; MAPK
资助项目Science & Technology Commission of Shanghai Municipality, China[18431907100] ; Special Research Assistant Project of the Chinese Academy of Sciences
WOS研究方向Cell Biology ; Immunology
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000656866800005
源URL[http://119.78.100.183/handle/2S10ELR8/297021]  
专题中国科学院上海药物研究所
通讯作者Li, Heng; Tang, Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Xiang, Caigui,Liu, Moting,Lu, Qiukai,et al. Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis[J]. CELLULAR IMMUNOLOGY,2021,365:10.
APA Xiang, Caigui.,Liu, Moting.,Lu, Qiukai.,Fan, Chen.,Lu, Huimin.,...&Tang, Wei.(2021).Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis.CELLULAR IMMUNOLOGY,365,10.
MLA Xiang, Caigui,et al."Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis".CELLULAR IMMUNOLOGY 365(2021):10.

入库方式： OAI收割

来源：上海药物研究所

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