中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum

文献类型：期刊论文

作者Yang, Fan1,2,3,4; Hua, Qiang1,3; Yao, Li-Gong2; Liang, Lin-Fu5; Lu, Yan-Hua1,3; An, Fa-Liang1,3; Guo, Yue-Wei2
刊名FITOTERAPIA
出版日期2021-06-01
卷号151页码:4
关键词Soft coral Litophyton nigrum Nardosinane
ISSN号0367-326X
DOI10.1016/j.fitote.2021.104906
通讯作者An, Fa-Liang(flan2016@ecust.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Further chemical investigation of the Xisha soft coral Litophyton nigrum has resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely linardosinenes D-G (1-4). The structures of new compounds were elucidated by extensive analyses of their spectroscopic data and by comparison with the reported data of known related ones. All compounds exhibited weak inhibitory effect against bromodomain-containing protein 4 (BRD4), a promising therapeutic target in various human diseases, at a concentration of 10 mu M.
资助项目National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[41876194]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000655328000001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/297032]  
专题新药研究国家重点实验室
通讯作者An, Fa-Liang; Guo, Yue-Wei
作者单位1.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China
3.Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China
4.Shanghai Normal Univ, Coll Life & Environm Sci, Dept Biol, 100 Guilin Rd, Shanghai 200234, Peoples R China
5.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Fan,Hua, Qiang,Yao, Li-Gong,et al. Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum[J]. FITOTERAPIA,2021,151:4.
APA Yang, Fan.,Hua, Qiang.,Yao, Li-Gong.,Liang, Lin-Fu.,Lu, Yan-Hua.,...&Guo, Yue-Wei.(2021).Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum.FITOTERAPIA,151,4.
MLA Yang, Fan,et al."Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum".FITOTERAPIA 151(2021):4.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。