ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling
文献类型：期刊论文
| 作者 | Xu, Cuidi1; Shi, Hongli1; Jiang, Xin1; Fan, Yongqian2; Huang, Donghui2; Qi, Xinming3 ; Cheng, Qun1
|
| 刊名 | FRONTIERS IN MOLECULAR BIOSCIENCES
 |
| 出版日期 | 2021-05-24 |
| 卷号 | 8页码:11 |
| 关键词 | ZEB1 osteogenesis Wnt/beta-catenin postmenopausal osteoporosis BMSCs |
| DOI | 10.3389/fmolb.2021.682728 |
| 通讯作者 | Qi, Xinming(xmqi@cdser.simm.ac.cn) ; Cheng, Qun(chengqun@fudan.edu.cn) |
| 英文摘要 | Zinc finger E-box-binding homebox 1 (ZEB1) is a zinc-finger transcription factor best known for its role in promoting the epithelial-mesenchymal transition, which is also related to osteogenesis. Here, ZEB1 was investigated for its role in the commitment of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts. In vitro, ZEB1 expression decreased following osteogenic differentiation. Furthermore, silencing of ZEB1 in BMSCs promoted osteogenic activity and mineralization. The increase in osteogenic differentiation induced by si-ZEB1 could be partly rescued by the inhibition of Wnt/beta-catenin (si-beta-catenin). In vivo, knockdown of ZEB1 in BMSCs inhibited the rapid bone loss of ovariectomized (OVX) mice. ZEB1 expression has also been negatively associated with bone mass and bone formation in postmenopausal women. In conclusion, ZEB1 is an essential transcription factor in BMSC differentiation and may serve as a potential anabolic strategy for treating and preventing postmenopausal osteoporosis (PMOP). |
| WOS关键词 | DELTA-EF1 ; REPRESSES ; EXPRESSION ; LOOP |
| 资助项目 | National Natural Science Foundation of China (NSFC)[81471089] ; National Key R&D Program of China[2018YFC2000201] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000658430100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297053]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Qi, Xinming; Cheng, Qun |
| 作者单位 | 1.Fudan Univ, Shanghai Geriatr Inst, Res Sect Geriatr Metab Bone Dis, Dept Osteoporosis & Bone Dis,Huadong Hosp, Shanghai, Peoples R China 2.Fudan Univ, Huadong Hosp, Dept Orthoped, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Cuidi,Shi, Hongli,Jiang, Xin,et al. ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8:11. |
| APA | Xu, Cuidi.,Shi, Hongli.,Jiang, Xin.,Fan, Yongqian.,Huang, Donghui.,...&Cheng, Qun.(2021).ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling.FRONTIERS IN MOLECULAR BIOSCIENCES,8,11. |
| MLA | Xu, Cuidi,et al."ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021):11. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。