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beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery

文献类型：期刊论文

作者Singh, Parbeen1,2,3; Chen, Yongli1,2; Tyagi, Deependra4; Wu, Li3; Ren, Xiaohong3; Feng, Jinglong1; Carrier, Andrew5,6; Luan, Tiangang2; Tang, Yongjun1; Zhang, Jiwen3,7
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2021-06-01
卷号602页码:10
关键词Targeted drug delivery Supramolecular polymer Hyaluronic acid-cyclodextrin pH-responsive drug release
ISSN号0378-5173
DOI10.1016/j.ijpharm.2021.120602
通讯作者Tang, Yongjun(tangyongjun@szpt.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Zhang, Xu(Xu_Zhang@cbu.ca)
英文摘要13-Cyclodextrin (13-CD) was grafted onto hyaluronic acid (HA) in a single step to generate a supramolecular biopolymer (HA-13-CD) that was explored for targeted drug delivery applications. Along with its excellent biocompatibility, the prepared HA-13-CD exhibits not only exceptionally high loading capacity for the model drugs doxorubicin and Rhodamine B through the formation of inclusion complexes with the 13-CD component, but also the capability of targeted drug delivery to cancerous cells with a high level of expression of CD44 receptors, attributable to its HA component. The polymer can release the drug under slightly acidic conditions. With all its attributes, HA-13-CD may be a promising cancer-cell-targeting drug carrier.
WOS关键词TUMOR ; BIOMATERIALS ; COMPLEX ; BINDING ; PH
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; National Science and Technology Major Project[2017ZX09101001006] ; Postdoctoral Foundation Project of Shenzhen Polytechnic[6019330006K] ; Postdoctoral Foundation Project of Shenzhen Polytechnic[6019330007K] ; Shenzhen Science and Technology Program[GJHZ20180928161212140] ; Cape Breton University RISE program ; NSERC ; Canada Research Chairs program
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000659060400001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/297088]  
专题中国科学院上海药物研究所
通讯作者Tang, Yongjun; Zhang, Jiwen; Zhang, Xu
作者单位1.Shenzhen Polytech, Shenzhen Key Lab Fermentat Purificat & Anal, Dept Biol Appl Engn, Postdoctoral Innovat Practice Base, Shenzhen 518055, Peoples R China
2.Sun Yat Sen Univ, Sch Marine Sci, State Key Lab Biocontrol, Guangzhou 51027, Peoples R China
3.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
4.Shenzhen Univ, Sch Basic Med Sci, Sch Med, Shenzhen 518060, Guangdong, Peoples R China
5.Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada
6.Cape Breton Univ, Dept Hlth Sci, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada
7.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714		 Singh, Parbeen,Chen, Yongli,Tyagi, Deependra,et al. beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2021,602:10.
APA Singh, Parbeen.,Chen, Yongli.,Tyagi, Deependra.,Wu, Li.,Ren, Xiaohong.,...&Zhang, Xu.(2021).beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery.INTERNATIONAL JOURNAL OF PHARMACEUTICS,602,10.
MLA Singh, Parbeen,et al."beta-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery".INTERNATIONAL JOURNAL OF PHARMACEUTICS 602(2021):10.

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来源：上海药物研究所

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