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Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma

文献类型：期刊论文

作者Geng, Huan1; Zhou, Mengxue2,3; Li, Bin1; Liu, Liang1; Yang, Xu1; Wen, Yinxian1; Yu, Haijun5,6; Wang, Hui4; Chen, Jun2,3; Chen, Liaobin1
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2021-08-01
卷号417页码:11
ISSN号1385-8947
关键词Metal-drug nanoparticles Orthotopic osteosarcoma Osteolytic microenvironment Zoledronate Radiotherapy
DOI10.1016/j.cej.2020.128103
通讯作者Wang, Hui(wanghui19@whu.edu.cn) ; Chen, Jun(chenjun@ihep.ac.cn) ; Chen, Liaobin(lbchen@whu.edu.cn)
英文摘要Osteosarcoma is the most common primary malignant bone tumor with the pathological essence of osteolysis, which seriously reduces the quality of life. To improve the treatment of osteosarcoma, current strategies focus on inhibiting osteolysis and cancer cell growth through combination therapy. Here, we firstly developed a new "carrier free" core-shell metal-drug nanoparticles to enhance the treatment of orthotopic osteosarcoma through inhibiting osteoclast activity and sensitizing radiotherapy. The core was formed by self-assembly of ferric ions with zoledronate (ZOL). The resultant nanoparticles with active pharmaceutical ingredient (API) content over 60 wt% and changeless ingredients of Fe and ZOL can induce efficient cell death and easy for large-scale synthesis. In addition, the inbuilt ZOL and surface modified hyaluronic acid could make the nanoparticles escape skeleton absorption and increase the concentration of zoledronate at the tumor site. Once accumulated in tumor, the released ZOL attenuated osteoclast activity around the tumors to prevent osteolysis. Meanwhile, the free radicals generated efficiently from HA@FeZOL through Fenton-like reaction sensitized radiotherapy to kill the tumor cells. The results corroborated the feasibility of HA@FeZOL mediated synergistic therapy against orthotopic osteosarcoma through sensitized radiotherapy and osteolysis inhibition. Therefore, this facile nanoplatform provides a new combinatorial strategy for treating osteosarcoma and opens a window for the application of metal-drug nanoparticles.
WOS关键词BISPHOSPHONATES ; ANGIOGENESIS ; CHEMOTHERAPY ; STABILITY ; DESIGN
资助项目National Natural Science Foundation of China[81972036] ; National Natural Science Foundation of China[81673490] ; National Natural Science Foundation of China[81603214] ; National Natural Science Foundation of China[21574136] ; National Key R&D Program of China[SQ2020YFA080035]
WOS研究方向Engineering
语种英语
出版者ELSEVIER SCIENCE SA
WOS记录号WOS:000653229500127
源URL[http://119.78.100.183/handle/2S10ELR8/297096]  
专题新药研究国家重点实验室
通讯作者Wang, Hui; Chen, Jun; Chen, Liaobin
作者单位1.Wuhan Univ, Dept Orthoped Surg, Zhongnan Hosp, Wuhan 430071, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Multidisciplinary Res Div, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Univ Chinese Acad Sci UCAS, Beijing 100049, Peoples R China
4.Wuhan Univ, Dept Pharmacol, Hubei Prov Key Lab Dev Originated Dis, Basic Med Sch, Wuhan 430071, Peoples R China
5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Geng, Huan,Zhou, Mengxue,Li, Bin,et al. Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma[J]. CHEMICAL ENGINEERING JOURNAL,2021,417:11.
APA Geng, Huan.,Zhou, Mengxue.,Li, Bin.,Liu, Liang.,Yang, Xu.,...&Chen, Liaobin.(2021).Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma.CHEMICAL ENGINEERING JOURNAL,417,11.
MLA Geng, Huan,et al."Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma".CHEMICAL ENGINEERING JOURNAL 417(2021):11.

入库方式： OAI收割

来源：上海药物研究所

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