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Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii

文献类型：期刊论文

作者Wang, Xing1,2,3; Peng, Xia1,2,4; Tang, Chunping1,2; Zhou, Shuaizhen1,2; Ke, Chang-Qiang1,2; Liu, Yueling4,5; Yao, Sheng1,2,3; Ai, Jing4; Ye, Yang1,2,3,5
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2021-05-28
卷号84期号:5页码:1626-1637
ISSN号0163-3864
DOI10.1021/acs.jnatprod.1c00177
通讯作者Yao, Sheng(yaosheng@simm.ac.cn) ; Ai, Jing(jai@simm.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn)
英文摘要Fourteen new eudesmane sesquiterpenoids (1, 35, 7-16) and seven known analogues were isolated from the whole plant of Artemisia hedinii. Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were confirmed by X-ray diffraction experiments and TDDFT ECD calculation. Compounds 1-15 were identified as eudesmane acids, which represent a kind of lactone ring-opening eudesmane-type sesquiterpenes with an acetoxyl or a hydroxy group attached to C-9. Compounds 1 and 2, 5 and 6, and 7 and 8 are three pairs of epimers isomerized at C-3, C-5, and C-11, respectively. Compounds 1-9, 11-13, 15-19, and 21 could influence the proinflammatory phenotype of the M1 macrophage. Among them, compounds 5, 8, 9, 12, 16, and 19 consistently exhibited anti-inflammatory effects, as evidenced by downregulating classic pro-inflammatory cytokines TNF-alpha, IL-12, IL-6, and IFN-gamma in LPS-induced primary bone marrow derived M1 macrophages.
WOS关键词DERIVATIVES ; LACTONES
资助项目National Key R&D Program of China[2018YFC1707000] ; National Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China[81903485] ; National Natural Science Foundation of China[21920102003]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000657373100024
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/297103]  
专题新药研究国家重点实验室
通讯作者Yao, Sheng; Ai, Jing; Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xing,Peng, Xia,Tang, Chunping,et al. Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(5):1626-1637.
APA Wang, Xing.,Peng, Xia.,Tang, Chunping.,Zhou, Shuaizhen.,Ke, Chang-Qiang.,...&Ye, Yang.(2021).Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii.JOURNAL OF NATURAL PRODUCTS,84(5),1626-1637.
MLA Wang, Xing,et al."Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii".JOURNAL OF NATURAL PRODUCTS 84.5(2021):1626-1637.

入库方式： OAI收割

来源：上海药物研究所

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