Four new diterpenoids from the twigs and leaves of Phyllanthus acidus
文献类型：期刊论文
| 作者 | Yuan, Yu-Rong2,3; Li, Yan-Wen4; Huang, Yi-Qi2,4; Liu, Qun-fang2 ; Ren, Yu-Hao2; Yue, Jian-Min1,2,3; Zhou, Bin2,3
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2021-07-02 |
| 卷号 | 91页码:6 |
| 关键词 | Phyllanthus acidus Cleistanthane-type diterpenoid ECD calculation Biosynthetic pathway Cytotoxicity |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2021.132224 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) ; Zhou, Bin(zbbrush@126.com) |
| 英文摘要 | Four new ent-cleistanthane type diterpenoids, phyacioids AeD (1-4), along with two known analogues (5 and 6) were isolated from the powered twigs and leaves of Phyllanthus acidus. Compound 1 was characterized as the third reported structure that possesses a 4,5-seco-20(10 -> 5)-abeo-(ent)-cleistanthane scaffold, and compounds 2 and 3 feature a rare alkynyl group. The structures of 1-4 were assigned by spectroscopic data, with their absolute structures being determined through electric circular dichroism (ECD) calculations. Compounds 3, 5 and 6 showed moderate cytotoxicity with IC50 values ranging from 13.8 to 36.0 mM. (C) 2021 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ANTIOXIDANT ; BIOSYNTHESIS ; FRUITS |
| 资助项目 | National Natural Science Foundation[21772212] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Jiangmen Program for Pnnovative Research Team[2018630100180019806] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000663121600016 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297118]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min; Zhou, Bin |
| 作者单位 | 1.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yu-Rong,Li, Yan-Wen,Huang, Yi-Qi,et al. Four new diterpenoids from the twigs and leaves of Phyllanthus acidus[J]. TETRAHEDRON,2021,91:6. |
| APA | Yuan, Yu-Rong.,Li, Yan-Wen.,Huang, Yi-Qi.,Liu, Qun-fang.,Ren, Yu-Hao.,...&Zhou, Bin.(2021).Four new diterpenoids from the twigs and leaves of Phyllanthus acidus.TETRAHEDRON,91,6. |
| MLA | Yuan, Yu-Rong,et al."Four new diterpenoids from the twigs and leaves of Phyllanthus acidus".TETRAHEDRON 91(2021):6. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。