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Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

文献类型：期刊论文

作者Zhang, Lanfei1,2; Zhang, Xiaofei2; Cui, Yongmei1; Yang, Chunhao2
刊名SYNTHESIS-STUTTGART
出版日期2021-05-17
页码12
关键词picolinamide 3,3-difluoroindolines 3-fluoroindoles directing groups
ISSN号0039-7881
DOI10.1055/a-1509-8624
通讯作者Cui, Yongmei(ymcui@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenylethan1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.
WOS关键词DECARBOXYLATIVE FLUORINATION ; INDOLE ; PICOLINAMIDE ; DERIVATIVES ; INHIBITORS ; TRIFLUOROMETHYLATION ; ALKENES ; ACIDS
资助项目Science and Technology Commission of Shanghai Municipality[18431907100] ; State Key Laboratory of Drug Research[SIMM193ZZ-03] ; Science
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000661613500001
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/297188]  
专题新药研究国家重点实验室
通讯作者Cui, Yongmei; Yang, Chunhao
作者单位1.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Lanfei,Zhang, Xiaofei,Cui, Yongmei,et al. Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling[J]. SYNTHESIS-STUTTGART,2021:12.
APA Zhang, Lanfei,Zhang, Xiaofei,Cui, Yongmei,&Yang, Chunhao.(2021).Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling.SYNTHESIS-STUTTGART,12.
MLA Zhang, Lanfei,et al."Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling".SYNTHESIS-STUTTGART (2021):12.

入库方式： OAI收割

来源：上海药物研究所

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