Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don
文献类型：期刊论文
| 作者 | Fang, Qiang-Qiang1,3; Feng, Tong-Tong2; Wang, Ai-Zhu2; He, Wan-Ying1,3; Wei, Ren-Jie1,3; Lu, Qun2; Tan, Chang-Heng1,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 187页码:7 |
| 关键词 | PPAPs Hypericum uralum Clusiaceae Antioxidant Cytotoxicity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.112771 |
| 通讯作者 | Lu, Qun(luqun1125@126.com) ; Tan, Chang-Heng(chtan@simm.ac.cn) |
| 英文摘要 | Uralins A - D, four undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) featuring an unprecedented fused hexacyclic architecture, a unique monocyclic tetra-seco-tetranor-b-PPAP, an oxidative b-PPAP and a rare norspiroindane-type m-PPAP, respectively, were isolated from the aerial parts of Hypericum uralum, along with ten known PPAPs. Their structures and absolute configurations were elucidated by extensive spectroscopic techniques (MS, NMR, [alpha](D), CD), conceivable biogenetic pathways and time-dependent density functional theory-based electronic circular dichroism (TDDFT-ECD) calculations. Biological assays showed three b-PPAPs had moderate antioxidative damage activities, while spiroindanes exhibited moderate cytotoxic effects. |
| WOS关键词 | PHLOROGLUCINOL DERIVATIVES ; HYPERFORIN |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, of the National Health Commission of China[2018ZX09735001-002-005] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, of the National Health Commission of China[2019ZX09201001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000654130400021 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297213]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, Qun; Tan, Chang-Heng |
| 作者单位 | 1.Chinese Acad Sci, Nat Prod Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610000, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Qiang-Qiang,Feng, Tong-Tong,Wang, Ai-Zhu,et al. Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don[J]. PHYTOCHEMISTRY,2021,187:7. |
| APA | Fang, Qiang-Qiang.,Feng, Tong-Tong.,Wang, Ai-Zhu.,He, Wan-Ying.,Wei, Ren-Jie.,...&Tan, Chang-Heng.(2021).Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don.PHYTOCHEMISTRY,187,7. |
| MLA | Fang, Qiang-Qiang,et al."Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don".PHYTOCHEMISTRY 187(2021):7. |
入库方式： OAI收割
来源：上海药物研究所
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