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Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides

文献类型：期刊论文

作者Li, Yuan1,2,3; Fang, Feifei2,3; Zhou, Jianhui2,3; Li, Jiyuan2,3; Wang, Run2,3; Liu, Hong2,3,4; Zhou, Yu2,3,4
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2021-05-11
页码7
关键词Isoquinoline N-oxides beta-hydroxy elimination Rhodium Secondary propargyl alcohols
ISSN号1615-4150
DOI10.1002/adsc.202100239
通讯作者Liu, Hong(hliu@simm.ac.cn)
英文摘要A beta-hydroxy elimination instead of common oxidization to carbonyl group in secondary propargyl alcohols was successfully developed to form 2-benzyl substituted isoquinoline N-oxides by a Rhodium-catalyzed C-H activation and annulation cascade, in which moderate to excellent yields (up to 92%) could be obtained under mild reaction conditions, along with good regioselectivity, broad generality and applicability.
WOS关键词BOND ACTIVATION ; 4+1 ANNULATION ; FUNCTIONALIZATION ; BENZAMIDES ; ACCESS ; ALLENYLATION ; ALKALOIDS ; ISOINDOLINONES ; DERIVATIVES ; CYCLIZATION
资助项目National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; Shanghai Science and Technology Development Funds[19431901000] ; Shanghai Science and Technology Development Funds[19431901200] ; Science and Technology Commission of Shanghai Municipality[18JC1411304] ; Youth Innovation Promotion Association CAS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000649190400001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/297217]  
专题新药研究国家重点实验室
通讯作者Liu, Hong
作者单位1.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yuan,Fang, Feifei,Zhou, Jianhui,et al. Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides[J]. ADVANCED SYNTHESIS & CATALYSIS,2021:7.
APA Li, Yuan.,Fang, Feifei.,Zhou, Jianhui.,Li, Jiyuan.,Wang, Run.,...&Zhou, Yu.(2021).Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides.ADVANCED SYNTHESIS & CATALYSIS,7.
MLA Li, Yuan,et al."Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides".ADVANCED SYNTHESIS & CATALYSIS (2021):7.

入库方式： OAI收割

来源：上海药物研究所

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