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Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones

文献类型：期刊论文

作者Li, Shunyao1,2; Zhang, Lanfei1; He, Qian1; Zhang, Xiaofei1; Yang, Chunhao1,2
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
出版日期2021-05-20
页码5
ISSN号1477-0520
DOI10.1039/d1ob00463h
通讯作者Zhang, Xiaofei(xiaofeizhang@simm.ac.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要An efficient and mild synthetic approach for 2-alkyl-substituted chroman-4-ones via zinc-mediated cascade decarboxylative beta-alkylation and dechlorination of 3-chlorochromones was developed. This transformation employed commercially available starting materials and was performed under mild conditions without heat, visible light, peroxide or heavy metals. Moreover, various alkyl NHPI esters with functional groups and differently substituted 3-chlorochromones were tolerated, affording the targeted products with moderate to excellent yields. This protocol could be utilized to construct a diverse library of 2-substituted chroman-4-one derivatives, which could be useful in the discovery of lead compounds for drug discovery in the future.
WOS关键词CONJUGATE ADDITION ; CHROMAN-4-ONE ; DERIVATIVES ; CHROMONE ; INHIBITORS ; REAGENTS
资助项目Science and Technology Commission of Shanghai Municipality[18431907100] ; NSFC[81872722] ; State Key Laboratory of Drug Research Program[SIMM1903ZZ-03]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000655187500001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/297220]  
专题新药研究国家重点实验室
通讯作者Zhang, Xiaofei; Yang, Chunhao
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shunyao,Zhang, Lanfei,He, Qian,et al. Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021:5.
APA Li, Shunyao,Zhang, Lanfei,He, Qian,Zhang, Xiaofei,&Yang, Chunhao.(2021).Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones.ORGANIC & BIOMOLECULAR CHEMISTRY,5.
MLA Li, Shunyao,et al."Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones".ORGANIC & BIOMOLECULAR CHEMISTRY (2021):5.

入库方式： OAI收割

来源：上海药物研究所

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