Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall
文献类型：期刊论文
| 作者 | Huang, Jin-Chang1; Liu, Yi-Nan2; Tao, Yun-Hua2,4; Chen, Bai-Yu1; Lei, Chun1; Fu, Wei1; Li, Jing-Ya2,4 ; Hu, Xiao3; Hou, Ai-Jun1
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 187页码:7 |
| 关键词 | Syzygium oblatum Wall Myrtaceae Acylphloroglucinols Oblatones A-I ATP citrate lyase |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.112765 |
| 通讯作者 | Hu, Xiao(xjtuyxhx@126.com) ; Hou, Ai-Jun(ajhou@shmu.edu.cn) |
| 英文摘要 | Nine undescribed acylphloroglucinol derivatives, oblatones A I, along with three known ones, were isolated from Syzygium oblatum. Their structures were determined on the basis of extensive spectroscopic analysis, including NMR and MS data interpretation. Oblatones A and B possess an alkylated chromanone scaffold featuring a hemiketal moiety. Oblatones C and D are the first acylphloroglucinol derivatives with an alpha,beta-unsaturated ketone lipid chain. Some of the isolates showed inhibitory effects on ATP citrate lyase in vitro. The binding mode of oblatone A was predicted by molecular docking. |
| WOS关键词 | PHLOROGLUCINOL DERIVATIVES |
| 资助项目 | Fudan-SIMM Joint Research Fund[FU-SIMM20181011] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000654130400015 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297230]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Hu, Xiao; Hou, Ai-Jun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Jin-Chang,Liu, Yi-Nan,Tao, Yun-Hua,et al. Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall[J]. PHYTOCHEMISTRY,2021,187:7. |
| APA | Huang, Jin-Chang.,Liu, Yi-Nan.,Tao, Yun-Hua.,Chen, Bai-Yu.,Lei, Chun.,...&Hou, Ai-Jun.(2021).Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall.PHYTOCHEMISTRY,187,7. |
| MLA | Huang, Jin-Chang,et al."Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall".PHYTOCHEMISTRY 187(2021):7. |
入库方式： OAI收割
来源：上海药物研究所
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