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Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking

文献类型：期刊论文

作者Chen, Ling1,2; Yao, Changliang2; Li, Jiayuan2; Wang, Jing2,3; Yao, Shuai2; Shen, Shijie2; Yang, Lin2; Zhang, Jianqing2; Wei, Wenlong2; Bi, Qirui2
刊名JOURNAL OF SEPARATION SCIENCE
出版日期2021-05-29
页码11
关键词feature‐ based molecular networking linear ion trap‐ Orbitrap Mahuang decoction traditional Chinese medicine
ISSN号1615-9306
DOI10.1002/jssc.202100121
通讯作者Guo, De-an(daguo@simm.ac.cn)
英文摘要Comprehensive characterization of traditional Chinese medicine prescriptions has long been a hurdle due to the chemical complexity and the lack of analytical tools. Mahuang decoction is a well-known traditional Chinese medicine prescription widely used for sweating and relieving the exterior, relieving cough and asthma, but it was insufficiently chemically scrutinized. In this study, the chemical component information of Mahuang decoction was investigated by ultrahigh-performance liquid chromatography tandem linear ion trap-Orbitrap mass spectrometry. A new data processing tool, feature-based molecular networking, was introduced for grouping and elucidating the compounds. In this way, 156 chemical components were identified or tentatively characterized, including alkaloids, triterpenoid saponins, flavanone-O-glycosides, flavone-C-glycosides, and procyanidins. Thus, this research provides a solid foundation for further development of Mahuang decoction, and the adopted method is expected to be applied to other traditional Chinese medicine prescriptions.
WOS关键词SIMULTANEOUS QUANTIFICATION ; MEDICINE ; STRATEGY
资助项目NationalKeyRDProgramofChina[2019YFC1711400] ; NationalKeyRDProgramofChina[2019YFC1711000] ; NationalKeyRDProgramofChina[2018YFC1707900] ; NationalNatural Science Foundation of China[82003938]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000655854300001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/297237]  
专题中国科学院上海药物研究所
通讯作者Guo, De-an
作者单位1.Nanjing Univ Chinese Med, Sch Pharm, Nanjing, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Haike Rd 501, Shanghai 201203, Peoples R China
3.Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Ling,Yao, Changliang,Li, Jiayuan,et al. Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking[J]. JOURNAL OF SEPARATION SCIENCE,2021:11.
APA Chen, Ling.,Yao, Changliang.,Li, Jiayuan.,Wang, Jing.,Yao, Shuai.,...&Guo, De-an.(2021).Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking.JOURNAL OF SEPARATION SCIENCE,11.
MLA Chen, Ling,et al."Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking".JOURNAL OF SEPARATION SCIENCE (2021):11.

入库方式： OAI收割

来源：上海药物研究所

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