Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Feng, Zheling1; Chen, Jiali1; Feng, Lu2,3; Chen, Cheng1; Ye, Yang2,3 ; Lin, Ligen1
|
| 刊名 | FOOD & FUNCTION
 |
| 出版日期 | 2021-05-12 |
| 页码 | 10 |
| ISSN号 | 2042-6496 |
| DOI | 10.1039/d1fo00972a |
| 通讯作者 | Lin, Ligen() |
| 英文摘要 | Ten new polyisoprenylated benzophenone derivatives, 4,8-epi-uralione F (1), 4,8-epi-uralione G (2), uralione S (3), coccinone J (4), 6-epi-coccinone C (5), coccinone I (6), 36-hydroxy-guttiferone J (7), multiftorone I (8), garciniagifolone F (9) and 36-hydroxy-garciniagifolone F (10), were isolated from the fruits of Garcinia cambogia, along with seven known analogues. The structures of the new compounds were established based on the detailed analysis of 1D and 2D nuclear magnetic resonance (NMR) spectra and high resolution electrospray ionization mass spectrometra (HRESIMS), and their absolute configurations were determined from the electronic circular dichroism (ECD) spectra. All the isolates were tested for their inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The results indicated that compound 1 displayed a potent NO inhibitory effect with an IC50 value of 41.60 +/- 0.17 mu M. Furthermore, compound 1 suppressed inducible NO synthase (iNOS) expression in a dose-dependent manner through inhibiting the activation of nuclear factor-kappa B (NF-kappa B). |
| WOS关键词 | (-)-HYDROXYCITRIC ACID ; HCA-SX ; FRUITS ; INFLAMMATION ; EXTRACTION ; XANTHONE ; WEIGHT ; INDICA |
| 资助项目 | National Natural Science Foundation of China[81872754] ; Science and Technology Development Fund, Macau SAR[0031/2019/A1] ; University of Macau[MYRG2018-00037-ICMS] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000656555200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297253]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lin, Ligen |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Zheling,Chen, Jiali,Feng, Lu,et al. Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities[J]. FOOD & FUNCTION,2021:10. |
| APA | Feng, Zheling,Chen, Jiali,Feng, Lu,Chen, Cheng,Ye, Yang,&Lin, Ligen.(2021).Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities.FOOD & FUNCTION,10. |
| MLA | Feng, Zheling,et al."Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities".FOOD & FUNCTION (2021):10. |
入库方式： OAI收割
来源：上海药物研究所
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