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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones

文献类型：期刊论文

作者Li, Jiyuan1,2; Fang, Feifei2; Wang, Run2; Li, Yuan2; Xu, Bin1; Liu, Hong2,3,4; Zhou, Yu2,3,4
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2021-05-13
页码7
ISSN号2052-4129
DOI10.1039/d1qo00387a
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn)
英文摘要A Rh(iii)-catalyzed C-H activation and regiospecific annulation cascade of benzoic acid with propargyl acetate was developed to produce an unreported 3-alkylidene-isochromanone scaffold. The biggest merit of this reaction is achieving the regioselective control in the alkyne insertion and the precise removal of the acetyl group to eventually form 3-alkylidene-isochromanone scaffolds possessing an unusual exocyclic double bond with moderate to excellent yields (up to 93%) under mild temperature along with broad generality and versatility.
WOS关键词AEROBIC OXIDATION ; CARBOXYLIC-ACIDS ; BOND ACTIVATION ; REGIOSELECTIVE SYNTHESIS ; DIRECTING GROUPS ; ORTHO-ARYLATION ; AROMATIC-ACIDS ; ALKYNES ; ISOCOUMARINS ; CYCLIZATION
资助项目National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; Shanghai Science and Technology Development Funds[19431901000] ; Shanghai Science and Technology Development Funds[19431901200] ; Science and Technology Commission of Shanghai Municipality[18JC1411304]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000655722700001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/297256]  
专题新药研究国家重点实验室
通讯作者Liu, Hong; Zhou, Yu
作者单位1.Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jiyuan,Fang, Feifei,Wang, Run,et al. A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones[J]. ORGANIC CHEMISTRY FRONTIERS,2021:7.
APA Li, Jiyuan.,Fang, Feifei.,Wang, Run.,Li, Yuan.,Xu, Bin.,...&Zhou, Yu.(2021).A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones.ORGANIC CHEMISTRY FRONTIERS,7.
MLA Li, Jiyuan,et al."A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones".ORGANIC CHEMISTRY FRONTIERS (2021):7.

入库方式： OAI收割

来源：上海药物研究所

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