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Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources

文献类型：期刊论文

作者Anicic, Neda1; Gasic, Uros1; Lu, Feng2,3; Ciric, Ana1; Ivanov, Marija1; Jevtic, Bojan4; Dimitrijevic, Milena5; Andelkovic, Boban6; Skoric, Marijana1; Nestorovic Zivkovic, Jasmina1
刊名PHARMACEUTICALS
出版日期2021-05-01
卷号14期号:5页码:22
关键词Nepeta nepetalactone 1,5,9-epideoxyloganic acid antimicrobial activity antibiofilm immunomodulatory effects
DOI10.3390/ph14050414
通讯作者Gasic, Uros(uros.gasic@ibiss.bg.ac.rs) ; Misic, Danijela(dmisic@ibiss.bg.ac.rs)
英文摘要Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
WOS关键词ESSENTIAL OIL ; NEPETALACTONES ; CONSTITUENTS ; ACID ; L. ; COMPONENTS ; LAMIACEAE ; CULTURES ; EXTRACT
资助项目Ministry of Education, Science and Technological Development of the Republic of Serbia[451-03-68/2020-14/200007] ; Ministry of Education, Science and Technological Development of the Republic of Serbia[451-03-9/2021-14/200007] ; President's International Fellowship Initiative (PIFI) grant (2019), Fellowship from the Chinese Academy of Sciences (CAS)
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000654389200001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/297283]  
专题新药研究国家重点实验室
通讯作者Gasic, Uros; Misic, Danijela
作者单位1.Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovi, Dept Plant Physiol, Bulevar Despota Stefana 142, Belgrade 11060, Serbia
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
4.Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovi, Dept Immunol, Bulevar Despota Stefana 142, Belgrade 11060, Serbia
5.Univ Belgrade, Inst Multidisciplinary Res, Ctr Excellence Green Technol, Kneza Viseslava 1, Belgrade 11030, Serbia
6.Univ Belgrade, Fac Chem, POB 51, Belgrade 11000, Serbia
推荐引用方式
GB/T 7714		 Anicic, Neda,Gasic, Uros,Lu, Feng,et al. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources[J]. PHARMACEUTICALS,2021,14(5):22.
APA Anicic, Neda.,Gasic, Uros.,Lu, Feng.,Ciric, Ana.,Ivanov, Marija.,...&Misic, Danijela.(2021).Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources.PHARMACEUTICALS,14(5),22.
MLA Anicic, Neda,et al."Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources".PHARMACEUTICALS 14.5(2021):22.

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来源：上海药物研究所

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