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Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides

文献类型：期刊论文

作者Hu, Shulei1,2; Han, Xu2; Xie, Xiong2; Fang, Feifei1,2; Wang, Yong2; Saidahmatov, Abdusaid2; Liu, Hong1,2,3; Wang, Jiang2,3
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2021-05-17
页码8
关键词annulation reactions C-H activation pyrazolidinone Rhodium (III)-catalyzed sulfoxonium ylide
ISSN号1615-4150
DOI10.1002/adsc.202100324
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Wang, Jiang(jwang@simm.ac.cn)
英文摘要A method to synthesize pyrazolo[1,2-a]cinnolines via rhodium(III)-catalyzed C-H activation of pyrazolidinones and subsequent [4+2] annulation of sulfoxonium ylides was developed. 5-Substituted or 5,10-disubstituted pyrazolo[1,2-a]cinnolines could be obtained by slightly adjusting the reaction conditions. Gram-scale synthesis and practical transformations proved the practicability of this method. The mechanism of this method was proposed in the article on the basis of preliminary mechanistic results and previous reports. This method features simplified operation, metal-oxidant free, and readily available reactants.
WOS关键词C-H ACTIVATION ; ACYLMETHYLATION ; PYRAZOLONES ; DERIVATIVES ; CYCLIZATION ; CINNOLINES
资助项目National Natural Science Foundation of China[91953108] ; National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81903434] ; Science and Technology Commission of Shanghai Municipality[18JC1411304] ; Science and Technology Commission of Shanghai Municipality[18431907100]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000651478100001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/297295]  
专题新药研究国家重点实验室
通讯作者Liu, Hong; Wang, Jiang
作者单位1.China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
3.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Shulei,Han, Xu,Xie, Xiong,et al. Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides[J]. ADVANCED SYNTHESIS & CATALYSIS,2021:8.
APA Hu, Shulei.,Han, Xu.,Xie, Xiong.,Fang, Feifei.,Wang, Yong.,...&Wang, Jiang.(2021).Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides.ADVANCED SYNTHESIS & CATALYSIS,8.
MLA Hu, Shulei,et al."Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides".ADVANCED SYNTHESIS & CATALYSIS (2021):8.

入库方式： OAI收割

来源：上海药物研究所

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