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Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1 beta inhibitors

文献类型：期刊论文

作者Xu, Yunshao1; Zhang, Tian1; Feng, Lu2,3; Feng, Zheling1; Zhang, Qingwen1; Ye, Yang2,3,4; Gan, Lishe5; Lin, Ligen1
刊名CHINESE CHEMICAL LETTERS
出版日期2021-04-01
卷号32期号:4页码:1475-1479
关键词Caesalpinia minax IL-1 beta Dimeric cassane diterpenoids NLRP3 TD-DFT
ISSN号1001-8417
DOI10.1016/j.cclet.2020.09.048
通讯作者Gan, Lishe(ganlishe@126.com) ; Lin, Ligen(ligenl@um.edu.mo)
英文摘要To search naturally occurring interleukin-1 beta (IL-1 beta) inhibitors, biscaesalmins A (1) and B (2), two highly oxidized dimeric cassane diterpenoids with a newly formed alicyclic skeleton, have been isolated from the traditional Chinese medicine Kushilian (Caesalpinia minax). Their full structures were determined by comprehensive spectroscopic analysis and quantum chemical TD-DFT (time-dependent density functional theory) calculation. Biosynthetically, 1 and 2 were formed via an intermolecular [4 + 2] Diels-Alder cycloaddition of two monomers, affording an additional six-membered carbon ring linkage. Compounds 1 and 2 inhibited nitric oxide production on lipopolysaccharide-stimulated THP-1 macrophages, with IC50 values being at 1.20 +/- 0.23 and 2.30 +/- 0.15 mu mol/L, respectively. Furthermore, compound 1 inhibited NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasomemediated IL-1 beta production and blocked the migration of macrophages towards adipocyte conditioned medium. Biscaesalmins A and B might be candidates for treating inflammation-related metabolic diseases. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
WOS关键词SEEDS
资助项目Science and Technology Development Fund, Macau SAR[FDCT 0031/2019/A1] ; National Natural Science Foundation of China[81872754] ; National Natural Science Foundation of China[81872756] ; University of Macau, Macau SAR[MYRG2017-00109-ICMS] ; University of Macau, Macau SAR[MYRG2018-00037-ICMS]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000644727600006
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/297301]  
专题新药研究国家重点实验室
通讯作者Gan, Lishe; Lin, Ligen
作者单位1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macau, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
5.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yunshao,Zhang, Tian,Feng, Lu,et al. Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1 beta inhibitors[J]. CHINESE CHEMICAL LETTERS,2021,32(4):1475-1479.
APA Xu, Yunshao.,Zhang, Tian.,Feng, Lu.,Feng, Zheling.,Zhang, Qingwen.,...&Lin, Ligen.(2021).Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1 beta inhibitors.CHINESE CHEMICAL LETTERS,32(4),1475-1479.
MLA Xu, Yunshao,et al."Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1 beta inhibitors".CHINESE CHEMICAL LETTERS 32.4(2021):1475-1479.

入库方式： OAI收割

来源：上海药物研究所

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