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Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols

文献类型：期刊论文

作者Wang, Siqi1,2; Miao, Erfei1,2; Wang, Hao1,2; Song, Bichao1,2; Huang, Wei1,2,3; Yang, Weibo1,2,3
刊名CHEMICAL COMMUNICATIONS
出版日期2021-05-05
页码4
ISSN号1359-7345
DOI10.1039/d1cc01778k
通讯作者Huang, Wei(huangwei@simm.ac.cn) ; Yang, Weibo(yweibo@simm.ac.cn)
英文摘要Merging both C-H and C-C activation in a tandem process is a marked challenge. A novel Rh(iii)-catalyzed C-H activation/ring opening C-C cleavage/cyclization of carboxylic acids with cyclopropanols was developed for the synthesis of 3-substituted phthalides and alpha,beta-butenolides. This reaction displays excellent functional group tolerance with respect to both carboxylic acids and cyclopropanols and features relatively mild conditions. Remarkably, the utility of this method was highlighted by the rapid construction of bioactive compounds bearing a 3-substituted phthalide framework via late-stage functionalization.
WOS关键词SYNTHETIC METHODOLOGIES ; BOND FORMATION ; PHTHALIDES ; CLEAVAGE
资助项目NSFC[21702217] ; 1000-Youth Talents Plan'', Shanghai-Youth Talent, National Science & Technology Major Project Key New Drug Creation and Manufacturing Program'' China[2018ZX09711002-006] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Shanghai-Technology Innovation Action Plan[18JC1415300] ; 100 talent program of Chinese Academy of Sciences
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000652541300001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/297305]  
专题中国科学院上海药物研究所
通讯作者Huang, Wei; Yang, Weibo
作者单位1.Chinese Acad Sci, CAS Key Lab Receptor Res, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Siqi,Miao, Erfei,Wang, Hao,et al. Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols[J]. CHEMICAL COMMUNICATIONS,2021:4.
APA Wang, Siqi,Miao, Erfei,Wang, Hao,Song, Bichao,Huang, Wei,&Yang, Weibo.(2021).Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols.CHEMICAL COMMUNICATIONS,4.
MLA Wang, Siqi,et al."Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols".CHEMICAL COMMUNICATIONS (2021):4.

入库方式： OAI收割

来源：上海药物研究所

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