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Ximaoglaucumins A-F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum

文献类型：期刊论文

作者Shen, Shou-Mao1,2; Li, Wang-Sheng2,3; Ding, Xun4,5; Luo, Hui3; Zhang, Hai-Yan4,5; Guo, Yue-Wei1,2
刊名BIOORGANIC & MEDICINAL CHEMISTRY
出版日期2021-05-15
卷号38页码:10
关键词Soft coral Sarcophyton glaucum Cembranoids Anti-inflammation
ISSN号0968-0896
DOI10.1016/j.bmc.2021.116139
通讯作者Luo, Hui(luohui@gdmu.edu.cn) ; Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Six new cembrane-type diterpenoids, namely ximaoglaucumins A-F (1?6), along with fifteen known related ones (7?10 and 14?24), have been isolated from the soft coral Sarcophyton glaucum collected off the Ximao Island in the South China Sea. Their structures, including absolute stereochemistry, were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) methods, X-ray diffraction analysis, chemical methods, as well as comparison with the reported data in the literature. Further, detailed analysis of spectroscopic data of 7 not only clarified the confusions regarding 7, 11 (sarcophytolol) and 12/13 (sarcotrocheliol) in the literature, but also led to revise the structure of 11, which was mis-assigned due to careless/erroneous interpretation of the 2D NMR spectra, and to correct the structures of 12/13, which were both wrongly depicted. In in vitro bioassay, compounds 8 and 20 exhibited potent inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells.
WOS关键词ANTI-TUMOR-PROMOTER ; MARINE TERPENES ; DITERPENOIDS ; TROCHELIOPHORUM ; BISCEMBRANOIDS ; METABOLITES ; CHEMISTRY ; REVISION
资助项目Natural Science Foundation of China[81991521] ; National Key Research and Development Program of China[2018YFC0310903] ; Science and Technology Commission of Shanghai Municipality[18430712500] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM2013ZZ-06]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000646150400012
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/297323]  
专题新药研究国家重点实验室
通讯作者Luo, Hui; Zhang, Hai-Yan; Guo, Yue-Wei
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
3.Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Medial, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Shou-Mao,Li, Wang-Sheng,Ding, Xun,et al. Ximaoglaucumins A-F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2021,38:10.
APA Shen, Shou-Mao,Li, Wang-Sheng,Ding, Xun,Luo, Hui,Zhang, Hai-Yan,&Guo, Yue-Wei.(2021).Ximaoglaucumins A-F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum.BIOORGANIC & MEDICINAL CHEMISTRY,38,10.
MLA Shen, Shou-Mao,et al."Ximaoglaucumins A-F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum".BIOORGANIC & MEDICINAL CHEMISTRY 38(2021):10.

入库方式： OAI收割

来源：上海药物研究所

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