The ups, downs and new trends of IDO1 inhibitors
文献类型：期刊论文
| 作者 | Chen, Shulun1,2,3; Tan, Jing1,2,3; Zhang, Ao1,2,3,4
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2021-05-01 |
| 卷号 | 110页码:12 |
| 关键词 | Immunotherapy Cancer Indoleamine 2,3-dioxygenase Tryptophan 2,3-dioxygenase Inhibitors Checkpoint Inhibitor |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.104815 |
| 通讯作者 | Zhang, Ao(ao6919zhang@sjtu.edu.cn) |
| 英文摘要 | Cancer immunotherapy has become an emerging driving force in the development of innovative strategies to fight against cancer. Despite the significant clinical benefits that many cancer patients have gained, the generally average response rate of similar to 20% is far behind the expectation for immune checkpoint inhibitors (ICIs). Combination of ICIs with indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors is considered as an alternative solution and has proved effective in tremendous preclinical studies. However, the failure of phase III ECHO-301/KEYNOTE-252 trial seriously dampened the enthusiasm on the rationality of IDO1-targeting strategy. Fortunately, in spite of the ups and downs in the developmental journey of IDO1 inhibitors, multiple new approaches have been proposed to bridge the gap between lab to the clinic. Here, we review the recent advances in the development of small molecule inhibitors targeting IDO1 especially the new trend of IDO1 inhibitors after ECHO-301 clinical trials, including dual or pan-inhibitors targeting IDO1 and TDO or IDO2, apo-IDO1 inhibitors, IDO1 PROTACs, as well as other IDO1 inhibitors. |
| WOS关键词 | 2,3-DIOXYGENASE 1 INHIBITORS ; INDUCED PROTEIN-DEGRADATION ; HUMAN INDOLEAMINE 2,3-DIOXYGENASE ; DRUG DISCOVERY ; CANCER-IMMUNOTHERAPY ; GCN2 KINASE ; STAGE-III ; IN-VITRO ; INDOLEAMINE-2,3-DIOXYGENASE ; DERIVATIVES |
| 资助项目 | Shanghai Jiao Tong University[AF1700037] ; Shanghai Jiao Tong University[WF220217002] ; Shanghai Jiao Tong University[WH10117001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000647574400002 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297326]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Pharm, Pharm Ctr 10, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shulun,Tan, Jing,Zhang, Ao. The ups, downs and new trends of IDO1 inhibitors[J]. BIOORGANIC CHEMISTRY,2021,110:12. |
| APA | Chen, Shulun,Tan, Jing,&Zhang, Ao.(2021).The ups, downs and new trends of IDO1 inhibitors.BIOORGANIC CHEMISTRY,110,12. |
| MLA | Chen, Shulun,et al."The ups, downs and new trends of IDO1 inhibitors".BIOORGANIC CHEMISTRY 110(2021):12. |
入库方式： OAI收割
来源：上海药物研究所
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