Magnetism-mediated targeting hyperthermia-immunotherapy in "cold" tumor with CSF1R inhibitor
文献类型：期刊论文
| 作者 | Fang, Yuefei1,2; He, Yang2,3; Wu, Canhao1,2; Zhang, Meng2; Gu, Zeyun2,3; Zhang, Jiaxin2; Liu, Ergang4; Xu, Qin1; Asrorov, Akmal M.2; Huang, Yongzhuo2,3,4,5
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| 刊名 | THERANOSTICS
 |
| 出版日期 | 2021 |
| 卷号 | 11期号:14页码:6860-6872 |
| 关键词 | magnetic hyperthermia CSF1R inhibitor tumor microenvironment tumor-associated macrophage immune memory targeted delivery magnetic liposomes |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.57511 |
| 通讯作者 | Xu, Qin(xuqin@gzucm.edu.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | Background: Immunotherapy has profoundly changed the landscape of cancer management and represented the most significant breakthrough. Yet, it is a formidable challenge that the majority of cancers - the so-called "cold" tumors - poorly respond to immunotherapy. To find a general immunoregulatory modality that can be applied to a broad spectrum of cancers is an urgent need. Methods: Magnetic hyperthermia (MHT) possesses promise in cancer therapy. We develop a safe and effective therapeutic strategy by using magnetism-mediated targeting MHT-immunotherapy in "cold" colon cancer. A magnetic liposomal system modified with cell-penetrating TAT peptide was developed for targeted delivery of a CSF1R inhibitor (BLZ945), which can block the CSF1-CSF1R pathway and reduce M2 macrophages. The targeted delivery strategy is characterized by its magnetic navigation and TAT-promoting intratumoral penetration. Results: The liposomes (termed TAT-BLZmlips) can induce ICD and cause excessive CRT exposure on the cell surface, which transmits an "eat-me" signal to DCs to elicit immunity. The combination of MHT and BLZ945 can repolarize M2 macrophages in the tumor microenvironment to relieve immunosuppression, normalize the tumor blood vessels, and promote T-lymphocyte infiltration. The antitumor effector CD8(+) T cells were increased after treatment. Conclusion: This work demonstrated that TAT-BLZmlips with magnetic navigation and MHT can remodel tumor microenvironment and activate immune responses and memory, thus inhibiting tumor growth and recurrence. |
| WOS关键词 | POLARIZATION ; MACROPHAGES ; THERAPY |
| 资助项目 | National Key Research and Development Program of China[2019YFE0129400] ; NFSC[81925035] ; NFSC[81521005] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; Shanghai SciTech Innovation Initiative[19431903100] ; Shanghai SciTech Innovation Initiative[18430740800] ; Shanghai Collaborative Innovation Group of Early Diagnosis and Precise Treatment of Hemangiomas and Vascular Malformations[SSMU-ZDCX20180701] ; PIFI fellowship, CAS |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000648907500014 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297383]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Qin; Huang, Yongzhuo |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, 12 Jichang Rd, Guangzhou 510450, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, CAS, Zhongshan 528437, Peoples R China 5.NMPA Key Lab Qual Researchand Evaluat Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Yuefei,He, Yang,Wu, Canhao,et al. Magnetism-mediated targeting hyperthermia-immunotherapy in "cold" tumor with CSF1R inhibitor[J]. THERANOSTICS,2021,11(14):6860-6872. |
| APA | Fang, Yuefei.,He, Yang.,Wu, Canhao.,Zhang, Meng.,Gu, Zeyun.,...&Huang, Yongzhuo.(2021).Magnetism-mediated targeting hyperthermia-immunotherapy in "cold" tumor with CSF1R inhibitor.THERANOSTICS,11(14),6860-6872. |
| MLA | Fang, Yuefei,et al."Magnetism-mediated targeting hyperthermia-immunotherapy in "cold" tumor with CSF1R inhibitor".THERANOSTICS 11.14(2021):6860-6872. |
入库方式： OAI收割
来源：上海药物研究所
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