中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent

文献类型：期刊论文

作者Wang, Hai-Ming1,2; Xiong, Chao-Dong3,4; Chen, Xiao-Qu2; Hu, Chun1; Wang, Dong-Yu2
刊名ORGANIC LETTERS
出版日期2021-04-02
卷号23期号:7页码:2595-2599
ISSN号1523-7060
DOI10.1021/acs.orglett.1c00504
通讯作者Hu, Chun(chunhu@syphu.edu.cn) ; Wang, Dong-Yu(wangdongyu@sjtu.edu.cn)
英文摘要Sulfamates and sulfamides are prevalent in biological molecules, but their universal synthetic methods are limited. We herein report a sulfamoylation agent with high solubility and shelf stability. Various sulfamates and sulfamides can be synthesized directly from alcohols or amines by employing this agent with high selectivity and high yields. This protocol was also successfully used for late-stage sulfamoylation of pharmaceuticals containing a hydroxyl or amino group.
WOS关键词NEDD8-ACTIVATING ENZYME-INHIBITOR ; UBIQUITIN-LIKE PROTEIN ; PEVONEDISTAT TAK-924/MLN4924 ; PHASE-I ; DERIVATIVES ; MLN4924
资助项目National Natural Science Foundation of China[21702216] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09711002006-003]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000637002800037
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/297390]  
专题中国科学院上海药物研究所
通讯作者Hu, Chun; Wang, Dong-Yu
作者单位1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hai-Ming,Xiong, Chao-Dong,Chen, Xiao-Qu,et al. Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent[J]. ORGANIC LETTERS,2021,23(7):2595-2599.
APA Wang, Hai-Ming,Xiong, Chao-Dong,Chen, Xiao-Qu,Hu, Chun,&Wang, Dong-Yu.(2021).Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent.ORGANIC LETTERS,23(7),2595-2599.
MLA Wang, Hai-Ming,et al."Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent".ORGANIC LETTERS 23.7(2021):2595-2599.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。