Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives
文献类型：期刊论文
| 作者 | Chen, Jian-Ping1; Li, Yi1; Liu, Chao2,3; Wang, Tianyi1,2,3; Chung, Lung Wa2,3; Xu, Ming-Hua1,2,3
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-01-15 |
| 卷号 | 23期号:2页码:571-577 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.0c04099 |
| 通讯作者 | Xu, Ming-Hua(xumh@sustech.edu.cn) |
| 英文摘要 | A highly enantioselective rhodium-catalyzed intermolecular hydroarylation of alpha-aminoalkyl acrylates using water as a direct proton source has been realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of alpha-aryl-methyl-substituted beta(2)-, gamma(2)-, and delta(2)-amino esters with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions. By utilizing this method, a series of structurally interesting benzo-fused heterocyclic molecules and the corresponding beta(2)-, gamma(2)-, and delta(2)-amino acids are facilely constructed. |
| WOS关键词 | CHIRAL DIENE LIGANDS ; ADDITION-ENANTIOSELECTIVE PROTONATION ; CONJUGATE ADDITION ; AMINO-ACIDS ; BETA(2)-AMINO ACIDS ; EFFICIENT ACCESS ; STEREOSELECTIVE-SYNTHESIS ; MICHAEL ADDITION ; OLEFIN LIGANDS ; BETA-PEPTIDES |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; National Natural Science Foundation of China[21971103] ; National Natural Science Foundation of China[21672229] ; National Natural Science Foundation of China[81521005] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000643163800058 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297401]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Dept Chem, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jian-Ping,Li, Yi,Liu, Chao,et al. Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives[J]. ORGANIC LETTERS,2021,23(2):571-577. |
| APA | Chen, Jian-Ping,Li, Yi,Liu, Chao,Wang, Tianyi,Chung, Lung Wa,&Xu, Ming-Hua.(2021).Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives.ORGANIC LETTERS,23(2),571-577. |
| MLA | Chen, Jian-Ping,et al."Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives".ORGANIC LETTERS 23.2(2021):571-577. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。