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Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer

文献类型：期刊论文

作者Wang, Jiaxin1,2,3; Zhou, Mengxue2,3; Chen, Fangmin2,3,4; Liu, Xiao5; Gao, Jin2,3; Wang, Weiqi5; Wang, Hui1; Yu, Haijun2,3,4
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
出版日期2021-08-01
卷号17期号:8页码:1486-1509
ISSN号1550-7033
关键词Cancer Immunotherapy Tumor Microenvironment Stimuli-Responsiveness Sheddable Nanoparticles Pathophysiological Barriers
DOI10.1166/jbn.2021.3134
通讯作者Wang, Weiqi(wwq1990@ntu.edu.cn) ; Wang, Hui(cewangh@imu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Immunotherapy displays potent potential for clinical cancer management by activating the protective immune response; however, the microenvironment of the immunosuppressive tumor restricts the efficiency of immunotherapies. Along with the complex pathophysiological barrier of the solid tumors, successful immunotherapeutic delivery remains a formidable challenge for conventional nanomedicine. Stimuli-sheddable nano vectors may facilitate the delivery of cargoes to tumors with minimal premature cargo leakage in blood circulation while enhancing the tumor penetration of nanomedicines by deshielding the polyethylene glycol (PEG) coroa upon endogenous activity such as acidity, enzymes and glu-IP: 27.0.0.1 On: Wed, 22 Sep 202 05:54 18 tathione, or external stimuli, such as laser irradiation. Throughout this study, researchers overviewed the recent advances Copyright: American Scentfic Publishers of nanomedicine-based cancer immunotherapy using the stimuli-responsive deshielding nano vectors, which allowed Delivered by Ingenta researchers to integrate multiple therapeutic regimens for inducing immunogenic cell death. This aided in blocking the immune checkpoints, repolarizing the macrophages, and regulating the kynurenine metabolism. Furthermore, researchers discussed the critical issues in the development of stimuli-sheddable nanoimmunodulators, primarily aimed at speeding up their clinical translation. Finally, researchers provided novel perspectives for improving cancer management with the stimuli-sheddable nanomedicine.
WOS关键词TUMOR-ASSOCIATED MACROPHAGES ; INTERSTITIAL FLUID PRESSURE ; IMMUNE CHECKPOINT BLOCKADE ; IMMUNOGENIC CELL-DEATH ; GROWTH-FACTOR VEGF ; M2 MACROPHAGES ; BREAST-CANCER ; PHOTODYNAMIC IMMUNOTHERAPY ; DELIVERY-SYSTEM ; GENE DELIVERY
资助项目National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31900990] ; Youth Innovation Promotion Associ-ation of Chinese Academy of Sciences[2014218] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of AppliedChemistry, Chinese Academy of Sciences
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER SCIENTIFIC PUBLISHERS
WOS记录号WOS:000701281700001
源URL[http://119.78.100.183/handle/2S10ELR8/297542]  
专题新药研究国家重点实验室
通讯作者Wang, Weiqi; Wang, Hui; Yu, Haijun
作者单位1.Inner Magnolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jiaxin,Zhou, Mengxue,Chen, Fangmin,et al. Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2021,17(8):1486-1509.
APA Wang, Jiaxin.,Zhou, Mengxue.,Chen, Fangmin.,Liu, Xiao.,Gao, Jin.,...&Yu, Haijun.(2021).Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,17(8),1486-1509.
MLA Wang, Jiaxin,et al."Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 17.8(2021):1486-1509.

入库方式： OAI收割

来源：上海药物研究所

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