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Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis

文献类型：期刊论文

作者Liu, Siyu1,2; Mao, Hui3; Qiao, Jin2; Zhang, Xiaoning2; Lu, Yangbin2; Gong, Xin1; Jia, Aiqiong1; Gu, Linghui1; Wu, Xiaowei4,5; Zhao, Fei1,2
刊名ASIAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2021-09-30
页码14
ISSN号2193-5807
关键词Iridium C-H activation [3+2] annulation Tetrasubstituted alkene pyrrolo[1,2-a]indole
DOI10.1002/ajoc.202100476
通讯作者Gu, Linghui(cdglh017@163.com) ; Wu, Xiaowei(wuxiaowei@simm.ac.cn) ; Zhao, Fei(zhaofei@cdu.edu.cn)
英文摘要We have achieved an Ir(III)-catalyzed temperature-controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1,2-a]indole derivatives through C-H alkenylation/DG migration and [3+2] annulation, respectively. This method has various advantageous features: a) excellent regio- and stereoselectivity and good functional group tolerance, b) broad substrate scope and moderate to excellent yields, c) mild redox-neutral reaction conditions and operational simplicity.
WOS关键词C-H ACTIVATION ; N BOND-FORMATION ; ESTROGEN-RECEPTOR MODULATION ; INTERNAL ALKYNES ; EFFICIENT ACCESS ; BENZOIC-ACIDS ; STEREOSELECTIVE HYDROARYLATION ; MOLECULAR PHARMACOLOGY ; PROPARGYL ALCOHOLS ; SULFONYL AZIDES
资助项目Zhejiang Provincial Natural Science Foundation of China[LQ19B020003] ; Zhejiang Provincial Natural Science Foundation of China[LY21B020003] ; Science and Technology Program of Sichuan Province[2018JY0345] ; National Natural Science Foundation of China[21602022] ; Chengdu Talents Program ; 1000 Talents Program of Sichuan Province ; Chenghua District Talents Program ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[1003] ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[SIIAJH-202002] ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[SIIAJH-202006] ; Jinhua Science and Technology Bureau[2021-3-150] ; Chengdu University[2081915037] ; Shanghai Pujiang Program[21PJ1415800]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000701848300001
源URL[http://119.78.100.183/handle/2S10ELR8/297546]  
专题中国科学院上海药物研究所
通讯作者Gu, Linghui; Wu, Xiaowei; Zhao, Fei
作者单位1.Chengdu Univ, Sch Pharm, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, 2025 Chengluo Ave, Chengdu 610106, Sichuan, Peoples R China
2.Chengdu Univ, Sch Pharm, Sichuan Ind Inst Antibiot, Jinhua Branch, 888 West Hai Tang Rd, Jinhua 321007, Zhejiang, Peoples R China
3.Jinhua Polytech, Coll Pharm, 888 West Hai Tang Rd, Jinhua 321007, Zhejiang, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Siyu,Mao, Hui,Qiao, Jin,et al. Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2021:14.
APA Liu, Siyu.,Mao, Hui.,Qiao, Jin.,Zhang, Xiaoning.,Lu, Yangbin.,...&Zhao, Fei.(2021).Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis.ASIAN JOURNAL OF ORGANIC CHEMISTRY,14.
MLA Liu, Siyu,et al."Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis".ASIAN JOURNAL OF ORGANIC CHEMISTRY (2021):14.

入库方式： OAI收割

来源：上海药物研究所

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