Combating liver cancer through GO-targeted biomaterials
文献类型：期刊论文
| 作者 | Huang, Xing1,2; Zhang, Jiaxin2; Song, Yijie2; Zhang, Tong1,2; Wang, Bing3 |
| 刊名 | BIOMEDICAL MATERIALS
 |
| 出版日期 | 2021-11-01 |
| 卷号 | 16期号:6页码:14 |
| 关键词 | graphene oxide hydroxycamptothecin anti-cancer drug delivery system targeting |
| ISSN号 | 1748-6041 |
| DOI | 10.1088/1748-605X/ac1f72 |
| 通讯作者 | Zhang, Tong(zhangtdmj@hotmail.com) ; Wang, Bing(bwang@simm.ac.cn) |
| 英文摘要 | Hydroxycamptothecin (HCPT) is a topoisomerase I inhibitor, and it has been widely used clinically in the treatment of primary liver cancer, gastric cancer, and other tumors. The clinical application of HCPT is limited by its water solubility, and it has certain toxicity to patients with tumor. Therefore, the effective tumor site accumulation of HCPT is necessary. This work studied the inhibitory effect of HCPT on the proliferation and migration of human liver cancer cells (HepG-2) and used carboxymethyl chitosan (CMC) and hyaluronic acid (HA) to modify graphene oxide (GO) as nano-carrier materials, which load HCPT to achieve a drug delivery system for liver tumors with good biocompatibility and high drug loading. HCPT can significantly inhibit proliferation and migration of HepG-2, enhance the release of reactive oxygen species, reduce mitochondrial membrane potential, and induce apoptosis. The GO-CMC-HA/HCPT drug delivery system enabled HepG-2 to uptake more HCPT, thereby inhibiting its proliferation and improving the efficacy of HCPT in vivo and in vitro. This study explored a potential therapy strategy by preparing a GO-based tumor-targeted drug delivery system. |
| WOS关键词 | DRUG-DELIVERY ; NANOPARTICLES ; 10-HYDROXYCAMPTOTHECIN ; GRAPHENE ; CAMPTOTHECIN ; LIPOSOMES ; APOPTOSIS ; OXIDE ; DNA |
| 资助项目 | Program of Shanghai Academic/Technology Research Leader[18XD1403700] ; National Science and Technology Major Project[2019ZX09201004-002] ; Key project of Shanghai 3 year plan[ZY (2018-2020)-CCCX-2001-04] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000692877500001 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297586]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Tong; Wang, Bing |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xing,Zhang, Jiaxin,Song, Yijie,et al. Combating liver cancer through GO-targeted biomaterials[J]. BIOMEDICAL MATERIALS,2021,16(6):14. |
| APA | Huang, Xing,Zhang, Jiaxin,Song, Yijie,Zhang, Tong,&Wang, Bing.(2021).Combating liver cancer through GO-targeted biomaterials.BIOMEDICAL MATERIALS,16(6),14. |
| MLA | Huang, Xing,et al."Combating liver cancer through GO-targeted biomaterials".BIOMEDICAL MATERIALS 16.6(2021):14. |
入库方式： OAI收割
来源：上海药物研究所
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