Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1
文献类型：期刊论文
| 作者 | Shi,Zhaopeng1; Gan,Guifang1; Xu,Xiang1; Zhang,Jieying1; Yuan,Yuan1; Bi,Bo2; Gao,Xianfu3; Xu,Pengfei4; Zeng,Wenbin4; Li,Jixi5 |
| 刊名 | Journal of Hematology & Oncology
 |
| 出版日期 | 2021-09-25 |
| 卷号 | 14期号:1 |
| 关键词 | 3-Hydroxyanthronic acid (3-HAA) Kynurenine YY1 DUSP6 Hepatocellular carcinoma (HCC) Tryptophan metabolism |
| DOI | 10.1186/s13045-021-01165-4 |
| 通讯作者 | Liu,Wen(w2liu@xmu.edu.cn) ; Lin,Shuhai(shuhai@xmu.edu.cn) ; Mi,Jun(jmei@sjtu.edu.cn) |
| 英文摘要 | AbstractThe 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in hepatocellular carcinoma by binding YY1. This 3-HAA binding of YY1 leads to phosphorylation of YY1 at the Thr 398 by PKCζ, concomitantly enhances YY1 chromatin binding activity to increase expression of target genes. These findings demonstrate that 3-HAA is a ligand of YY1, suggesting it is a promising therapeutic candidate for HCC. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S13045-021-01165-4 |
| 出版者 | BioMed Central |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297590]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu,Wen; Lin,Shuhai; Mi,Jun |
| 作者单位 | 1.Shanghai Jiao Tong University School of Medicine; Basic Medical Institute, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Tongren Hospital 2.Shanghai Jiao Tong University School of Medicine; Department of Nuclear Medicine, Rui Jin Hospital 3.Shanghai Profleader Biotech Co., Ltd 4.Central South University; Xiangya School of Pharmaceutical Sciences 5.Fudan University; School of Life Science 6.Chinese Academy of Sciences; CAS Key Laboratory of Receptor Research, Department of Analytical Chemistry, Shanghai Institute of Materia Medica 7.Xiamen University; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology 8.Xiamen University; School of Life Sciences, State Key Laboratory of Cellular Stress Biology |
| 推荐引用方式 GB/T 7714 | Shi,Zhaopeng,Gan,Guifang,Xu,Xiang,et al. Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1[J]. Journal of Hematology & Oncology,2021,14(1). |
| APA | Shi,Zhaopeng.,Gan,Guifang.,Xu,Xiang.,Zhang,Jieying.,Yuan,Yuan.,...&Mi,Jun.(2021).Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1.Journal of Hematology & Oncology,14(1). |
| MLA | Shi,Zhaopeng,et al."Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1".Journal of Hematology & Oncology 14.1(2021). |
入库方式： OAI收割
来源：上海药物研究所
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