中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale

文献类型:期刊论文

作者Fan, Yao-Yue1; Gan, Li-She2,3; Chen, Shi-Xin2; Gong, Qi4; Zhang, Hai-Yan4; Yue, Jian-Min1
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2021-08-20
卷号86期号:16页码:11277-11283
ISSN号0022-3263
DOI10.1021/acs.joc.1c00307
通讯作者Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Two eudesmane-guaiane/lindenane heterocoupled sesquiterpenoid dimers, horienoids A (1) and B (2) with new carbon skeletons, from Hedyosmum orientale were characterized by a combined method. Compound 1 featured a unique 2,10-dioxabicyclo[6.2.1]-undecane core moiety with an anti-Bredt bridgehead double bond. Their biogenetic pathways were proposed to involve Diels-Alder and cascade rearrangement reactions as the key steps. Compound 2 exhibited a potent anti-inflammatory effect on LPS-induced BV-2 microglial cells.
WOS关键词A-C ; CHLORANTHUS ; SPECTRA ; PLANTS
资助项目National Natural Science Foundation of China[21772213] ; National Natural Science Foundation of China[81872758] ; National Natural Science Foundation of China[81872859] ; Shanghai Rising-Star program Foundation (SCST)[19QA1410800] ; Youth Innovation Promotion Association, CAS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000687851300033
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/297664]  
专题新药研究国家重点实验室
通讯作者Yue, Jian-Min
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Peoples R China
3.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
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Fan, Yao-Yue,Gan, Li-She,Chen, Shi-Xin,et al. Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(16):11277-11283.
APA Fan, Yao-Yue,Gan, Li-She,Chen, Shi-Xin,Gong, Qi,Zhang, Hai-Yan,&Yue, Jian-Min.(2021).Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale.JOURNAL OF ORGANIC CHEMISTRY,86(16),11277-11283.
MLA Fan, Yao-Yue,et al."Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale".JOURNAL OF ORGANIC CHEMISTRY 86.16(2021):11277-11283.

入库方式: OAI收割

来源:上海药物研究所

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