Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale
文献类型：期刊论文
| 作者 | Fan, Yao-Yue1; Gan, Li-She2,3; Chen, Shi-Xin2; Gong, Qi4; Zhang, Hai-Yan4 ; Yue, Jian-Min1
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2021-08-20 |
| 卷号 | 86期号:16页码:11277-11283 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.1c00307 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Two eudesmane-guaiane/lindenane heterocoupled sesquiterpenoid dimers, horienoids A (1) and B (2) with new carbon skeletons, from Hedyosmum orientale were characterized by a combined method. Compound 1 featured a unique 2,10-dioxabicyclo[6.2.1]-undecane core moiety with an anti-Bredt bridgehead double bond. Their biogenetic pathways were proposed to involve Diels-Alder and cascade rearrangement reactions as the key steps. Compound 2 exhibited a potent anti-inflammatory effect on LPS-induced BV-2 microglial cells. |
| WOS关键词 | A-C ; CHLORANTHUS ; SPECTRA ; PLANTS |
| 资助项目 | National Natural Science Foundation of China[21772213] ; National Natural Science Foundation of China[81872758] ; National Natural Science Foundation of China[81872859] ; Shanghai Rising-Star program Foundation (SCST)[19QA1410800] ; Youth Innovation Promotion Association, CAS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000687851300033 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297664]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Peoples R China 3.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yao-Yue,Gan, Li-She,Chen, Shi-Xin,et al. Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(16):11277-11283. |
| APA | Fan, Yao-Yue,Gan, Li-She,Chen, Shi-Xin,Gong, Qi,Zhang, Hai-Yan,&Yue, Jian-Min.(2021).Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale.JOURNAL OF ORGANIC CHEMISTRY,86(16),11277-11283. |
| MLA | Fan, Yao-Yue,et al."Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale".JOURNAL OF ORGANIC CHEMISTRY 86.16(2021):11277-11283. |
入库方式： OAI收割
来源：上海药物研究所
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