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Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila

文献类型：期刊论文

作者Huo, Jiangyan1,2; Lei, Min1,2; Zhou, Yang1,2; Zhong, Xianchun1,2; Liu, Yameng1,2; Hou, Jinjun1,2; Long, Huali1,2; Zhang, Zijia1,2; Tian, Menghua3; Xie, Cen1,2
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2021-09-01
卷号186页码:501-509
关键词Gastrodia data Akkermansia muciniphila Polysaccharide
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2021.06.157
通讯作者Xie, Cen(xiecen@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要Two homogeneous polysaccharides, GEP-3 and GEP-4, were purified from Gastrodia data, a precious traditional Chinese medicine. Their structural characteristics were obtained using HPGPC, PMP-HPLC, LC/MS, FT-IR, NMR, and SEM methods. GEP-3 was 1,4-glucan with molecular weight of 20 kDa. Interestingly, GEP-4 comprised of a backbone of ->[4)-alpha-Glcp-(1](10)->[4)-alpha-Glcp-(1 ->](5)[6)-beta-Glcp-(1](11)-> 6)-alpha-Glcp-(3 -> and two branches of beta-Glcp and p-hydroxybenzyl alcohol citrate, with repeating p-hydroxybenzyl alcohol attached to the backbone chain at O-6 position of -> 4,6)-alpha-Glcp-(1 -> and O-1 position of -> 3,6)-alpha-Glcp-(1 -> GEP-4 is a novel polysaccharide obtained and characterized for the first time. Bioactivity test indicated that both of them significantly promote the growth of Akkermansia muciniphila (Akk. muciniphila). Furthermore, GEP-3 and GEP-4 promoted the growth of Akk. muciniphila from high-fat diet (HFD) fecal microbiota. These results indicated that GEP-3 and GEP-4 were potential Akk. muciniphila growth promoters.
WOS关键词RADICAL SCAVENGING ACTIVITIES ; GUT MICROBIOTA ; CONSTITUENTS ; ANTIOXIDANT ; RHIZOMES ; BL.
资助项目Special Fund for the National Key Research and Development Plan of China[2018YFC1707900] ; Special Fund for the National Key Research and Development Plan of China[2018YFC1707001] ; Special Fund for the National Key Research and Development Plan of China[2018YFC1707903] ; Special Fund for the National Key Research and Development Plan of China[2018YFC1707905]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000688434600006
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/297701]  
专题中国科学院上海药物研究所
通讯作者Xie, Cen; Wu, Wanying
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhaotong Tianma Res Inst, Zhaotong 657000, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Huo, Jiangyan,Lei, Min,Zhou, Yang,et al. Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,186:501-509.
APA Huo, Jiangyan.,Lei, Min.,Zhou, Yang.,Zhong, Xianchun.,Liu, Yameng.,...&Wu, Wanying.(2021).Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,186,501-509.
MLA Huo, Jiangyan,et al."Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 186(2021):501-509.

入库方式： OAI收割

来源：上海药物研究所

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