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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta

文献类型：期刊论文

作者Liu, Jiao1,2; Wu, Meng-Jun1,3,4; Li, Heng1; Wang, Hong3,4; Tang, Wei1; Gu, Yu-Cheng5; Li, Xu-Wen1,2; Guo, Yue-Wei1,3,4
刊名BIOORGANIC CHEMISTRY
出版日期2021-09-01
卷号114页码:8
关键词Soft coral Sinularia erecta Casbane Stereochemistry Anti-inflammatory activity
ISSN号0045-2068
DOI10.1016/j.bioorg.2021.105028
通讯作者Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要A further systematically chemical investigation of the South China Sea soft coral Sinularia erecta led to the discovery of two rare casbane diterpenoids with an uncommon 8,10-peroxide bridge, sinuereperoxides B (1) and C (2), five new casbanes with other oxygenated patterns (3-7), and seven known casbanes (8-14). The structures and absolute configurations of 1-7 were established by extensive spectroscopic data analyses, X-ray diffraction analysis, and/or quantum chemical calculations. In bioassay, compounds 2, 7, 11 and 12 exhibited considerable anti-inflammatory activity by the inhibition of TNF-alpha release, with IC50 values of 33.8 mu M, 5 mu M, 9.9 mu M and 8 mu M.
资助项目National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[82022069] ; National Natural Science Foundation of China (NSFC)[42076099] ; National Key Research and Development Program of China[2018YFC0310903] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] ; Syngenta-SIMM-PhD Studentship Project
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000689722000006
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/297718]  
专题新药研究国家重点实验室
通讯作者Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
4.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China
5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
推荐引用方式
GB/T 7714		 Liu, Jiao,Wu, Meng-Jun,Li, Heng,et al. Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta[J]. BIOORGANIC CHEMISTRY,2021,114:8.
APA Liu, Jiao.,Wu, Meng-Jun.,Li, Heng.,Wang, Hong.,Tang, Wei.,...&Guo, Yue-Wei.(2021).Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta.BIOORGANIC CHEMISTRY,114,8.
MLA Liu, Jiao,et al."Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta".BIOORGANIC CHEMISTRY 114(2021):8.

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来源：上海药物研究所

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