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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Discrete genetic loci in human gutBacteroides thetaiotaomicron confer pectin metabolism

文献类型：期刊论文

作者Li, Meixia1; Li, Saijuan1; Guo, Xiaozhen1; Guo, Ciliang1; Wang, Yeqin1; Du, Zhenyun1; Zhang, Zhenqing3,4; Xie, Cen1,2; Ding, Kan1,2
刊名CARBOHYDRATE POLYMERS
出版日期2021-11-15
卷号272页码:13
关键词Polysaccharide Pectin Human gut microbiota Metabolism Bacteroides
ISSN号0144-8617
DOI10.1016/j.carbpol.2021.118534
通讯作者Xie, Cen(xiecen@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn)
英文摘要Although the polysaccharide utilization loci (PULs) activated by pectin have been defined, due to the complex of side-chain structure, the degradative mechanisms still remain vague. Thus, we hypothesize that there may have other specific PULs to target pectin. Here, we characterize loci-encoded proteins expressed by Bacteroides thetaiotaomicron (BT) that are involved in the pectin capturing, importation, de-branching and degradation into monosaccharides. Totally, four PULs contain ten enzymes and four glycan binding proteins which including a novel surface enzyme and a surface glycan binding protein are identified. Notably, PUL2 and PUL3 have not been reported so far. Further, we show that the degradation products support the growth of other Bacteroides spp. and probiotics. In addition, genes involved in this process are conservative in other Bacteroides spp. Our results further highlight the contribution of Bacteroides spp. to metabolism the pectic network.
WOS关键词POLYSACCHARIDE UTILIZATION ; GUT MICROBIOTA ; CATABOLISM ; GALECTIN-3 ; DIVERSITY ; EVOLUTION
资助项目National Natural Science Foundation of China[31800673] ; Key New Drug Creation andManufacturing Program[2019ZX09735001] ; National Key Research and Development Program of China, Ministry of Science and Technology[2019YFC1711-000]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000689507000007
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/297741]  
专题新药研究国家重点实验室
通讯作者Xie, Cen; Ding, Kan
作者单位1.Chinese Acad Sci, Glycochem & Glycobiol Lab, Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China
4.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Li, Meixia,Li, Saijuan,Guo, Xiaozhen,et al. Discrete genetic loci in human gutBacteroides thetaiotaomicron confer pectin metabolism[J]. CARBOHYDRATE POLYMERS,2021,272:13.
APA Li, Meixia.,Li, Saijuan.,Guo, Xiaozhen.,Guo, Ciliang.,Wang, Yeqin.,...&Ding, Kan.(2021).Discrete genetic loci in human gutBacteroides thetaiotaomicron confer pectin metabolism.CARBOHYDRATE POLYMERS,272,13.
MLA Li, Meixia,et al."Discrete genetic loci in human gutBacteroides thetaiotaomicron confer pectin metabolism".CARBOHYDRATE POLYMERS 272(2021):13.

入库方式： OAI收割

来源：上海药物研究所

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