Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
文献类型：期刊论文
| 作者 | Qu, Ke-Jun1; Wang, Bin1; Jiang, Chang-Sheng2; Xie, Bao-Gang3; Liu, Ai-Hong4; Li, Song-Wei5; Guo, Yue-Wei5 ; Li, Jia5; Mao, Shui-Chun1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2021-08-27 |
| 卷号 | 84期号:8页码:2303-2311 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.1c00403 |
| 通讯作者 | Mao, Shui-Chun(maoshuichun@ncu.edu.cn) |
| 英文摘要 | Two novel rearranged Diels-Alder adducts, morunigrines A (1) and B (2), and four new prenylated flavonoids, morunigrols A-D (3-6), were isolated from the twigs of Morus nigra, together with four known prenylated phenolic compounds, including two flavonoids (7 and 8) and two 2-arylbenzofurans ( 9 and 10). Morunigrines A (1) and B (2) are a novel class of Diels-Alder adducts with unprecedented carbon skeletons featuring a rearranged chalcone-stilbene/2-arylbenzofuran core decorated with a unique methylbiphenyl moiety. The structures of the new compounds were assigned by analysis of spectroscopic data. The absolute configuration of compound 6 was determined by the measurement of specific rotation. A plausible biogenetic pathway for 1 and 2 is also proposed. Compounds 1 and 2 exhibited more potent protein tyrosine phosphatase 1B inhibitory activity with IC50 values of 1.8 +/- 0.2 and 1.3 +/- 0.3 mu M, respectively, than that of the positive control oleanolic acid (IC50, 2.5 +/- 0.1 mu M). |
| WOS关键词 | CULTIVATED MULBERRY TREE ; ROOT BARK ; ALBA ; CONSTITUENTS ; PHYTOALEXINS ; ANTIOXIDANT ; MORACEAE |
| 资助项目 | National Natural Science Foundation of China[21362024] ; National Natural Science Foundation of China[81860616] ; National Natural Science Foundation of China[82060633] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; Natural Science Foundation of Jiangxi Province, China[20181BAB205086] ; Natural Science Foundation of Jiangxi Province, China[20202BAB206084] ; State Key Laboratory of Drug Research-SIMM[SIMM1803KF-01] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000692038100026 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297754]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Mao, Shui-Chun |
| 作者单位 | 1.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China 2.Jiangxi Prov Ctr Drug Certificat & Evaluat, Nanchang 330046, Jiangxi, Peoples R China 3.Jiaxing Univ, Dept Pharmaceut, Med Coll, Jiaxing 314001, Peoples R China 4.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, Ke-Jun,Wang, Bin,Jiang, Chang-Sheng,et al. Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(8):2303-2311. |
| APA | Qu, Ke-Jun.,Wang, Bin.,Jiang, Chang-Sheng.,Xie, Bao-Gang.,Liu, Ai-Hong.,...&Mao, Shui-Chun.(2021).Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra.JOURNAL OF NATURAL PRODUCTS,84(8),2303-2311. |
| MLA | Qu, Ke-Jun,et al."Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra".JOURNAL OF NATURAL PRODUCTS 84.8(2021):2303-2311. |
入库方式： OAI收割
来源：上海药物研究所
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