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Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain

文献类型：期刊论文

作者Shao, Fang-bing1; Fang, Jun-fan1; Wang, Si-si1; Qiu, Meng-ting1; Xi, Dan-ning1; Jin, Xiao-ming2; Liu, Jing-gen1,3; Shao, Xiao-mei1; Shen, Zui1; Liang, Yi1
刊名MOLECULAR BRAIN
出版日期2021-09-10
卷号14期号:1页码:22
关键词Chronic inflammatory pain Anxiety-like behavior GABAergic system Anterior cingulate cortex synaptic transmission
DOI10.1186/s13041-021-00849-9
通讯作者Fang, Jian-qiao(fangjiangiao7532@163.com) ; Du, Jun-ying(dujunying0706@163.com)
英文摘要Chronic pain easily leads to concomitant mood disorders, and the excitability of anterior cingulate cortex (ACC) pyramidal neurons (PNs) is involved in chronic pain-related anxiety. However, the mechanism by which PNs regulate pain-related anxiety is still unknown. The GABAergic system plays an important role in modulating neuronal activity. In this paper, we aimed to study how the GABAergic system participates in regulating the excitability of ACC PNs, consequently affecting chronic inflammatory pain-related anxiety. A rat model of CFA-induced chronic inflammatory pain displayed anxiety-like behaviors, increased the excitability of ACC PNs, and reduced inhibitory presynaptic transmission; however, the number of GAD65/67 was not altered. Interestingly, intra-ACC injection of the GABA(A)R agonist muscimol relieved anxiety-like behaviors but had no effect on chronic inflammatory pain. Intra-ACC injection of the GABA(A)R antagonist picrotoxin induced anxiety-like behaviors but had no effect on pain in normal rats. Notably, chemogenetic activation of GABAergic neurons in the ACC alleviated chronic inflammatory pain and pain-induced anxiety-like behaviors, enhanced inhibitory presynaptic transmission, and reduced the excitability of ACC PNs. Chemogenetic inhibition of GABAergic neurons in the ACC led to pain-induced anxiety-like behaviors, reduced inhibitory presynaptic transmission, and enhanced the excitability of ACC PNs but had no effect on pain in normal rats. We demonstrate that the GABAergic system mediates a reduction in inhibitory presynaptic transmission in the ACC, which leads to enhanced excitability of pyramidal neurons in the ACC and is associated with chronic inflammatory pain-related anxiety.
WOS关键词BRAIN CHANGES ; MOUSE MODEL ; INTERNEURONS ; ANXIETY ; GABA ; INHIBITION ; MODULATION ; MECHANISMS ; PLASTICITY ; DISORDERS
资助项目Zhejiang Provincial Natural Science Fund of China[Y19H270053] ; Zhejiang Medical and Health Science and Technology Program[2021RC098] ; National Natural Science Fund of China[81873360]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000694894500001
出版者BMC
源URL[http://119.78.100.183/handle/2S10ELR8/297829]  
专题中国科学院上海药物研究所
通讯作者Fang, Jian-qiao; Du, Jun-ying
作者单位1.Zhejiang Chinese Med Univ, Sch Clin Med 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou 310053, Peoples R China
2.Indiana Univ Sch Med, Stark Neurosci Res Inst, Dept Anat & Cell Biol, NB Bldg,320w 15th St 141, Indianapolis, IN 46202 USA
3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Shao, Fang-bing,Fang, Jun-fan,Wang, Si-si,et al. Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain[J]. MOLECULAR BRAIN,2021,14(1):22.
APA Shao, Fang-bing.,Fang, Jun-fan.,Wang, Si-si.,Qiu, Meng-ting.,Xi, Dan-ning.,...&Du, Jun-ying.(2021).Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain.MOLECULAR BRAIN,14(1),22.
MLA Shao, Fang-bing,et al."Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain".MOLECULAR BRAIN 14.1(2021):22.

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来源：上海药物研究所

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