Improving Stability of Vitamin B5 Through Double Salt Formation
文献类型：期刊论文
| 作者 | Liang, Xuan1,2; Zhang, Qi2; Zhang, Zaiyong2; Ding, Qiaoce2; Mei, Xuefeng2
|
| 刊名 | CRYSTAL GROWTH & DESIGN
 |
| 出版日期 | 2021-09-01 |
| 卷号 | 21期号:9页码:4997-5005 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/acs.cgd.1c00437 |
| 通讯作者 | Mei, Xuefeng(xuefengmei@simm.ac.cn) |
| 英文摘要 | Calcium pantothenate (CP) is a chemically unstable vitamin and sensitive to moisture, heat, acid, and alkali. The poor physicochemical properties have greatly limited its biological performance and applications. In this work, four new double salts of CP with pantoic acid calcium salt (PA), calcium isobutyrate (IBA), calcium beta-hydroxy-beta-methyl butyrate (HMB), and calcium lactate (LA) were synthesized aiming to reduce the moisture sensitivity and to enhance the stability. The three double salts (CP-PA, CP-IBA, CP-HMB) were fully characterized by single crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and dynamic vapor sorption. In addition, their hygroscopicity and chemical stability under different conditions were also studied. The results show that all four double salts present improved hygroscopicity, physical stability, and chemical stability. Notably, compared to CP pure forms, CP-PA and CP-LA present significantly lower moisture absorption and obviously improved stability. This work provides a new method to improve the hygroscopicity, physical stability, and chemical stability of organic salts. |
| WOS关键词 | ACID ; FORMS |
| 资助项目 | Major Nationa l Science and Technology[2017ZX09101001] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000693047300019 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297835]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | 1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Xuan,Zhang, Qi,Zhang, Zaiyong,et al. Improving Stability of Vitamin B5 Through Double Salt Formation[J]. CRYSTAL GROWTH & DESIGN,2021,21(9):4997-5005. |
| APA | Liang, Xuan,Zhang, Qi,Zhang, Zaiyong,Ding, Qiaoce,&Mei, Xuefeng.(2021).Improving Stability of Vitamin B5 Through Double Salt Formation.CRYSTAL GROWTH & DESIGN,21(9),4997-5005. |
| MLA | Liang, Xuan,et al."Improving Stability of Vitamin B5 Through Double Salt Formation".CRYSTAL GROWTH & DESIGN 21.9(2021):4997-5005. |
入库方式： OAI收割
来源：上海药物研究所
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