Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation
文献类型：期刊论文
| 作者 | Zhou, Yong1,2; Zhang, Meijuan2,3; Wang, Caifen2,3; Ren, Xiaohong2; Guo, Tao2; Cao, Zeying2,4; Zhang, Jiwen1,2 ; Sun, Lixin3; Wu, Li2
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2021-09-05 |
| 卷号 | 606页码:9 |
| 关键词 | D-Limonene gamma-cyclodextrin metal-organic framework Dry powder inhaler Solidification Aerosolization Bioavailability |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2021.120825 |
| 通讯作者 | Sun, Lixin(slx04@163.com) ; Wu, Li(wuli@simm.ac.cn) |
| 英文摘要 | D-Limonene (D-Lim), a volatile oil extracted from citrus fruits, has therapeutic effects on lung inflammation and cancer, whilst the deep delivery of D-Lim was challenging due to its physical instability for a long period of time. To prevent the volatilization of D-Lim and achieve efficient pulmonary delivery, herein, D-Lim was loaded into biodegradable gamma-cyclodextrin metal-organic framework (gamma-CD-MOF) with optimal loading efficiency achieving 13.79 +/- 0.01% (molar ratio of D-Lim and gamma-CD-MOF was 1.6:1), which possessed cubic shape with controllable particle size (1-5 mu m). The experimental results indicated that gamma-CD-MOF could improve the stability of D-Lim. A series of characterizations and molecular docking were used to reveal the interaction between D-Lim and gamma-CDMOF. The solidification of D-Lim by gamma-CD-MOF played a crucial role in the exploitation of its inhalable dosage form, dry powder inhaler (DPI). Specifically, the aerosolization of D-Lim@gamma-CD-MOF for inhalation was satisfactory with a fine particle fraction (FPF) of 33.12 +/- 1.50% at 65 L/min of flow rate. Furthermore, in vivo study had shown a 2.23-fold increase in bioavailability of D-Lim solidified by gamma-CD-MOF for inhalation compared to D Lim for oral administration. Therefore, it is considered that gamma-CD-MOF could be an excellent carrier for pulmonary drug delivery to realize solidification and lung therapeutic effects of volatile oils. |
| WOS关键词 | STABILITY ; CD ; ENCAPSULATION ; NANOCARRIERS ; INFLAMMATION ; FORMULATION ; COMPONENTS ; RELEASE ; CARRIER |
| 资助项目 | Research Foundation of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences[CASIMM0120182001] ; Key Program for International Science and Technology Cooperation Projects of China[2020YFE0201700] ; National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2018ZX09721002-009] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000692239100002 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297847]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sun, Lixin; Wu, Li |
| 作者单位 | 1.Jiangxi Univ Chinese Med, Sch Pharm, Nanchang 330004, Jiangxi, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, 103 Wenhua Rd, Shenyang 110016, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yong,Zhang, Meijuan,Wang, Caifen,et al. Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2021,606:9. |
| APA | Zhou, Yong.,Zhang, Meijuan.,Wang, Caifen.,Ren, Xiaohong.,Guo, Tao.,...&Wu, Li.(2021).Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation.INTERNATIONAL JOURNAL OF PHARMACEUTICS,606,9. |
| MLA | Zhou, Yong,et al."Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation".INTERNATIONAL JOURNAL OF PHARMACEUTICS 606(2021):9. |
入库方式： OAI收割
来源：上海药物研究所
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