Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents
文献类型：期刊论文
| 作者 | Wang, Wenwen1,2,3; Zhang, Zijia1,2; Deng, Yanping1,2; Yang, Zhixin1,2; Hou, Jinjun1,2 ; Long, Huali1,2; Lei, Min1,2; Wu, Wanying1,2
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| 刊名 | BIOSCIENCE TRENDS
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| 出版日期 | 2021-08-01 |
| 卷号 | 15期号:4页码:231-239 |
| 关键词 | Neuroinflammation Shenqi Fuzheng Injection (SFI) Arginase 1 (Arg1) Transforming growth factor beta-1 (Tgfb1) microglia |
| ISSN号 | 1881-7815 |
| DOI | 10.5582/bst.2021.01140 |
| 通讯作者 | Lei, Min(mlei@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn) |
| 英文摘要 | Enhancement of alternative activation (M2) in microglia is a promising therapeutic target for microglia-mediated neuroinflammation. Shenqi Fuzheng Injection (SFI) is a clinical adjuvant treatment for cancer to reduce the side effects during cancer treatment, including boosting mood and improving appetite. However, the mechanism of SFI's effects on central symptoms is not clear. Therefore, using arginase 1 (Arg1) and transforming growth beta-1 (Tgfb1) as markers for M2 microglia activation, we found that compounds 1, 5, 12, 14, and 15 are the major M2-promoting constituents in SFI, which significantly upregulated Arg1 or Tgfb1 gene expression. Our results suggested that these compounds in SFI may promote M2 microglial activation and have potential uses in modulating microglial activation and alleviating neuroinflammation. |
| WOS关键词 | INJURY ; NEUROGENESIS ; MICROGLIA ; PATHWAY ; MICE |
| 资助项目 | Youth Program of National Natural Science Foundation of China[82003939] ; Key Research and Development Projects in Guangdong Province of China[2020B1111110001] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000696511400001 |
| 出版者 | IRCA-BSSA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297860]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lei, Min; Wu, Wanying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Heilongjiang Univ Chinese Med, Harbin, Heilongjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wenwen,Zhang, Zijia,Deng, Yanping,et al. Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents[J]. BIOSCIENCE TRENDS,2021,15(4):231-239. |
| APA | Wang, Wenwen.,Zhang, Zijia.,Deng, Yanping.,Yang, Zhixin.,Hou, Jinjun.,...&Wu, Wanying.(2021).Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents.BIOSCIENCE TRENDS,15(4),231-239. |
| MLA | Wang, Wenwen,et al."Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents".BIOSCIENCE TRENDS 15.4(2021):231-239. |
入库方式： OAI收割
来源：上海药物研究所
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