Transfersomes improved delivery of ascorbic palmitate into the viable epidermis for enhanced treatment of melasma
文献类型：期刊论文
| 作者 | Li, Junjun1,2; Duan, Nianxiu1; Song, Sha1; Nie, Di1; Yu, Miaorong1; Wang, Jie1; Xi, Ziyue1; Li, Jingyi1; Sheng, Yingjie1; Xu, Can3 |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2021-10-25 |
| 卷号 | 608页码:10 |
| 关键词 | Transfersome Drug delivery Ascorbic palmitate Viable epidermis Melasma treatment |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2021.121059 |
| 通讯作者 | Wei, Yan(ywei@shu.edu.cn) ; Gan, Yong(ygan@simm.ac.cn) |
| 英文摘要 | Ascorbic palmitate (AP) is widely used in the topical pharmaceutical or cosmetic formulations for melasma treatment. However, the presence of the skin barriers makes it difficult for the highly lipophilic drug molecules to traverse the stratum corneum (SC) and diffuse into the viable epidermis (EP) to reach the melanocytes, thereby exerting suboptimal antimelasma effects. Herein, AP was encapsulated into the transfersomes (TFs), yielding APTFs. AP-TFs utilized the deformability of TFs to squeeze through the skin pores in the SC under the transepidermal hydration gradient forces, leading to 14.1-fold increase in AP accumulation to the EP. AP-TFs could slowly release the encapsulated AP, while whether the released AP or transfersomal AP showed comparable uptake into the melanocytes, thereby exerting similar inhibitory effects on tyrosinase activity and melanogenesis. Ultimately, in the rat melasma model, AP-TFs showed superior antimelasma efficacy to free AP, with effective relief of oxidative stress and inflammation in the skin. Moreover, AP-TFs did not induce skin irritation. Therefore, the study provides a safe and effective approach to elevating the delivery of highly lipophilic drugs to the EP for enhanced treatment of melasma. |
| WOS关键词 | TRANSDERMAL DELIVERY ; DRUG CARRIERS ; SKIN ; VESICLES ; FORMULATION ; LIPOSOMES ; BEHAVIOR ; INSULIN |
| 资助项目 | National Natural Science Foundation of China[82025032] ; National Natural Science Foundation of China[81872428] ; National Natural Science Foundation of China[81703010] ; National Key R&D Program of China[2020YFE0201700] ; China Postdoctoral Science Foundation[2016M600342] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000696700800003 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297863]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wei, Yan; Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China 3.Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China 4.Shanghai Univ, Inst Translat Med, Shanghai 200011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Junjun,Duan, Nianxiu,Song, Sha,et al. Transfersomes improved delivery of ascorbic palmitate into the viable epidermis for enhanced treatment of melasma[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2021,608:10. |
| APA | Li, Junjun.,Duan, Nianxiu.,Song, Sha.,Nie, Di.,Yu, Miaorong.,...&Gan, Yong.(2021).Transfersomes improved delivery of ascorbic palmitate into the viable epidermis for enhanced treatment of melasma.INTERNATIONAL JOURNAL OF PHARMACEUTICS,608,10. |
| MLA | Li, Junjun,et al."Transfersomes improved delivery of ascorbic palmitate into the viable epidermis for enhanced treatment of melasma".INTERNATIONAL JOURNAL OF PHARMACEUTICS 608(2021):10. |
入库方式： OAI收割
来源：上海药物研究所
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