Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements
文献类型：期刊论文
| 作者 | Huguet, Clement1; Real, Eleonore3; Zhao, Wei-Min2 ; Urbain, Aurelie1
|
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2021-02-01 |
| 卷号 | 41页码:88-91 |
| 关键词 | Pregnanes Cynanchum Apocynaceae Diabetes Glucagon-like peptide-1 Structure-activity relationships |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2020.11.008 |
| 通讯作者 | Urbain, Aurelie(urbain@unistra.fr) |
| 英文摘要 | In our continued efforts to explore the antidiabetic potential of pregnanes from Apocynaceae, especially from the Asclepiadoideae subfamily, sixteen derivatives 1-16 previously isolated from various Cynanchum species, have been evaluated for their ability to increase glucagon-like peptide-1 (GLP-1) release in a cell assay. As a result, otophylloside A (2), wilfoside C1N (13), and wilfoside C3N (16) were found to stimulate significantly the secretion of GLP-1, doubling the extracellular content of this incretin. Caudatin 3-O-beta-D glucopyranosyl-(1 -> 4)- beta-D-oleandropyranosyl-(1 -> 4)-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (6) was also bioactive, but to a lesser extent (133 % of secretion compared to control cells). This study confirms the potential of certain pregnane derivatives from subfamily Asclepiadoideae to stimulate the release of GLP-1, reduced in patients with type 2 diabetes. In addition, this study outlines some putative structure-activity relationships: the nature of the sugar chain at C-3, as well as the ester moiety at C-12 position appear to be key elements to stimulate GLP-1 secretion. |
| WOS关键词 | C-21 STEROIDAL GLYCOSIDES ; ROOTS ; ASCLEPIADACEAE ; CONSTITUENTS ; OTOPHYLLUM |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000697281100017 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297878]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Urbain, Aurelie |
| 作者单位 | 1.Univ Strasbourg, CNRS, IPHC UMR 7178, CAMBAP, F-67000 Strasbourg, France 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai, Peoples R China 3.Univ Strasbourg, CNRS, LBP UMR 7021, F-67000 Strasbourg, France |
| 推荐引用方式 GB/T 7714 | Huguet, Clement,Real, Eleonore,Zhao, Wei-Min,et al. Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements[J]. PHYTOCHEMISTRY LETTERS,2021,41:88-91. |
| APA | Huguet, Clement,Real, Eleonore,Zhao, Wei-Min,&Urbain, Aurelie.(2021).Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements.PHYTOCHEMISTRY LETTERS,41,88-91. |
| MLA | Huguet, Clement,et al."Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements".PHYTOCHEMISTRY LETTERS 41(2021):88-91. |
入库方式： OAI收割
来源：上海药物研究所
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