Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ
文献类型：期刊论文
| 作者 | Yang, Xinyu1,3,4; Zhang, Xianfeng2; Yang, Wei3; Yu, Hang1,4; He, Qianyan5; Xu, Hui1,4; Li, Shihui3; Shang, Zi'ao3; Gao, Xiaodong3; Wang, Yan1,4 |
| 刊名 | FRONTIERS IN ENDOCRINOLOGY
 |
| 出版日期 | 2021-09-06 |
| 卷号 | 12页码:14 |
| 关键词 | gut microbiota adipose tissue dysfunction molecular endocrinology cardiovascular disease(s) gut dysbiosis |
| ISSN号 | 1664-2392 |
| DOI | 10.3389/fendo.2021.749125 |
| 通讯作者 | Wang, Yan(wangyan@imm.ac.cn) ; Tong, Qian(tongqian@jlu.edu.cn) |
| 英文摘要 | The gut microbiome has emerged as a key regulator of host metabolism. Accumulating evidence has indicated that the gut microbiota is involved in the development of various human diseases. This association relies on the structure and metabolites of the gut microbiota. The gut microbiota metabolizes the diet ingested by the host into a series of metabolites, including short chain fatty acids, secondary bile acids, trimethylamine N-oxide, and branched-chain amino acids, which affects the physiological processes of the host by activating numerous signaling pathways. In this review, we first summarize the various mechanisms through which the gut microbiota influences adipose tissue dysfunction and metabolic processes that subsequently cause cardiovascular diseases, highlighting the complex interactions between gut microbes, their metabolites, and the metabolic activity of the host. Furthermore, we investigated the current status of clinical therapies for adipose tissue dysfunction directed at the gut microbiota. Finally, we discuss the challenges that remain to be addressed before this field of research can be translated to everyday clinical practice. |
| WOS关键词 | TRIMETHYLAMINE-N-OXIDE ; DIET-INDUCED OBESITY ; CHAIN FATTY-ACIDS ; LOW-GRADE INFLAMMATION ; INTESTINAL MICROBIOTA ; BARIATRIC SURGERY ; INSULIN-RESISTANCE ; GASTRIC BYPASS ; HEPATIC STEATOSIS ; PROGNOSTIC VALUE |
| 资助项目 | National Natural Science Foundation of China[81973290,82070362] ; Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study[Z141102004414062] ; Key Project of Beijing Natural Science Foundation[7181007] |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000697288100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297881]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Yan; Tong, Qian |
| 作者单位 | 1.Peking Union Med Coll, Inst Mat Medica, Beijing, Peoples R China 2.Jilin Univ, Dept Neurosurg, Affiliated Hosp 1, Changchun, Peoples R China 3.Jilin Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Changchun, Peoples R China 4.Chinese Acad Med Sci, Inst Mat Medica, Beijing, Peoples R China 5.Jilin Univ, Dept Neurol, Affiliated Hosp 1, Changchun, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xinyu,Zhang, Xianfeng,Yang, Wei,et al. Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ[J]. FRONTIERS IN ENDOCRINOLOGY,2021,12:14. |
| APA | Yang, Xinyu.,Zhang, Xianfeng.,Yang, Wei.,Yu, Hang.,He, Qianyan.,...&Tong, Qian.(2021).Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ.FRONTIERS IN ENDOCRINOLOGY,12,14. |
| MLA | Yang, Xinyu,et al."Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ".FRONTIERS IN ENDOCRINOLOGY 12(2021):14. |
入库方式： OAI收割
来源：上海药物研究所
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